Distribution and correlates of serum high-density lipoprotein subclasses (LpA-I and LpA-I:A-II) in children from a biracial community. The Bogalusa Heart Study.
Distribution and correlates of serum high-density lipoprotein subclasses (LpA-I and LpA-I:A-II) in children from a biracial community. The Bogalusa Heart Study.
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混血儿社区儿童血清高密度脂蛋白亚类（LpA-I 和 LpA-I:A-II）的分布和相关性。
DOI：
10.1016/s0026-0495(98)90042-7
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Berenson,GS
中科院分区：
文献类型：
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作者：
Srinivasan,SR;Elkasabany,A;Berenson,GS
高密度脂蛋白（HDL）亚类被认为在抗动脉粥样硬化潜力方面有所不同。因此，在基于社区的 5 至 17 岁黑人（n = 1,021）和白人（n = 1,087）儿童的随机子样本中检查了血清脂蛋白 A-I (LpA-I) 和 LpA-I:A-II 的分布和相关性。黑人儿童的 LpA-I 水平显着高于白人儿童。就 LpA-I:A-II 而言，青春期前（5 至 10 岁）黑人男性和青春期（11 至 17 岁）白人儿童的值显着高于同龄人。除了青春期前男性的 LpA-I:A-II 差异外，观察到的黑白差异与血清甘油三酯（HDL 的代谢相关性）的种族差异无关。除了青春期的 LpA-I 水平外，黑人和白人的两个 HDL 亚类都存在显着的性别差异（男性 > 女性）。在青春期年龄组中，14岁后LpA-I水平的男女交叉趋势（女性>男性）明显。性成熟和年龄是导致种族性别组之间HDL亚类水平变异的主要因素（负）；肥胖（阴性）、胰岛素（阴性）、酒精摄入（阳性）和口服避孕药的使用（阳性）是次要但重要的预测变量。就与其他脂蛋白变量的关系而言，与 LpA-I:A-II 相比，LpA-I 与 HDL 胆固醇的相关性更强。与 LpA-I 不同，LpA-I:A-II 与低密度脂蛋白 (LDL) 胆固醇显着（正）相关。这些发现表明不同种族、性别群体在生命早期存在内在代谢差异，导致 HDL 亚类模式和随之而来的抗动脉粥样硬化潜力存在差异。
High-density lipoprotein (HDL) subclasses are considered to differ in terms of antiatherogenic potential. Therefore, the distribution and correlates of serum lipoprotein A-I (LpA-I) and LpA-I:A-II were examined in a random community-based subsample of black (n = 1,021) and white (n = 1,087) children aged 5 to 17 years. Black children had significantly higher LpA-I levels than white children. With respect to LpA-I:A-II, prepubertal (age 5 to 10 years) black males and pubertal (age 11 to 17 years) white children showed significantly higher values than their counterparts. With the exception of the LpA-I:A-II difference among prepubertal males, the observed black-white difference was independent of the racial differential in serum triglycerides, a metabolic correlate of HDL. A significant sex differential (males > females) was noted among blacks and whites for both HDL subclasses, with the exception of LpA-I levels at the pubertal age. Among the pubertal age group, a male-female crossover trend (females > males) in LpA-I levels was apparent after age 14. Sexual maturation and age were the major factors (negative) contributing to the variability in the levels of HDL subclasses among race-sex groups; adiposity (negative), insulin (negative), alcohol intake (positive), and oral contraceptive use (positive) emerged as minor but significant predictor variables. In terms of a relation to other lipoprotein variables, LpA-I compared with LpA-I:A-II correlated much more strongly with HDL cholesterol. Unlike LpA-I, LpA-I:A-II was associated significantly (positively) with low-density lipoprotein (LDL) cholesterol. These findings are indicative of intrinsic metabolic differences among the race-sex groups early in life, resulting in variability in the HDL subclass pattern and attendant antiatherogenic potential.