Toward uniform implementation of parametric map Digital Imaging and Communication in Medicine standard in multisite quantitative diffusion imaging studies.
Toward uniform implementation of parametric map Digital Imaging and Communication in Medicine standard in multisite quantitative diffusion imaging studies.
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DOI：
10.1117/1.jmi.5.1.011006
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Newitt DC
中科院分区：
文献类型：
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作者：
Malyarenko D;Fedorov A;Bell L;Prah M;Hectors S;Arlinghaus L;Muzi M;Solaiyappan M;Jacobs M;Fung M;Shukla-Dave A;McManus K;Boss M;Taouli B;Yankeelov TE;Quarles CC;Schmainda K;Chenevert TL;Newitt DC
本文报告了由定量成像网络的MRI小组发起的一个多站点协作项目的结果，该项目旨在评估当前的能力，并为在利用定量扩散加权成像(DWI)的临床试验中生成标准的参数扩散图医学数字成像和通信(DICOM)提供指南。参与网站使用单个体模的多供应商DWI DICOM数据集，基于两个模型生成表观扩散系数(ADC)的参数图(PM)。对结果进行了评估，以确保模型之间的数字一致性和真实的幻影ADC值，以及元数据与DICOM标准所要求的属性的一致性。这一分析确定了描述ADC模型之间检测到的数字差异的来源的缺失的元数据。所有站点都将ADC地图存储为DICOM MR对象，而不是DICOM PM对象，通常缺乏用于定量DWI建模的指定属性和编码术语。被认为对数字一致性很重要的源图像参考、模型参数、ADC单位和比例要么丢失，要么使用非标准约定存储。根据已确定的限制，DICOM PM标准已进行了修订，以包括相关扩散模型的编码术语。开发了开放源码软件，以支持将特定地点的格式转换为标准表示法。
This paper reports on results of a multisite collaborative project launched by the MRI subgroup of Quantitative Imaging Network to assess current capability and provide future guidelines for generating a standard parametric diffusion map Digital Imaging and Communication in Medicine (DICOM) in clinical trials that utilize quantitative diffusion-weighted imaging (DWI). Participating sites used a multivendor DWI DICOM dataset of a single phantom to generate parametric maps (PMs) of the apparent diffusion coefficient (ADC) based on two models. The results were evaluated for numerical consistency among models and true phantom ADC values, as well as for consistency of metadata with attributes required by the DICOM standards. This analysis identified missing metadata descriptive of the sources for detected numerical discrepancies among ADC models. Instead of the DICOM PM object, all sites stored ADC maps as DICOM MR objects, generally lacking designated attributes and coded terms for quantitative DWI modeling. Source-image reference, model parameters, ADC units and scale, deemed important for numerical consistency, were either missing or stored using nonstandard conventions. Guided by the identified limitations, the DICOM PM standard has been amended to include coded terms for the relevant diffusion models. Open-source software has been developed to support conversion of site-specific formats into the standard representation.