Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles
Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles
复制标题
钴纳米粒子的皮摩尔灵敏度 MRI 和光声成像
DOI：
10.1073/pnas.0813019106
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发表时间：
2009-03-17
影响因子：
11.1
通讯作者：
Chen, Fanqing Frank
中科院分区：
文献类型：
--
作者：
Bouchard, Louis-S.;Anwar, M. Sabieh;Chen, Fanqing Frank
基于互补检测原理的多模态成像具有广泛的临床应用，有望提高医学诊断的准确性。这意味着示踪剂颗粒有利地将多个功能结合到单个递送载体中。在目前的工作中，我们探索了一种独特的MRI和光声断层扫描（PAT）的组合来检测纳米颗粒的皮摩尔浓度。该纳米结构由铁磁（Co）颗粒组成，该颗粒涂有金（Au）以实现生物相容性，并且具有独特的形状，能够在宽频率范围内吸收光。最终的结果是一个双模态探针用于检测生物组织中的纳米粒子的痕量，其中MRI提供体积检测，而PAT执行边缘检测。
Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.