Chronic ACE inhibitor treatment increases angiotensin type 1 receptor binding in vivo in the dog kidney
Chronic ACE inhibitor treatment increases angiotensin type 1 receptor binding in vivo in the dog kidney
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DOI：
10.1007/s00259-007-0667-z
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发表时间：
2008-06-01
影响因子：
9.1
通讯作者：
Szabo, Zsolt
中科院分区：
文献类型：
--
作者：
Zober, Tamas G.;Fabucci, Maria Elena;Szabo, Zsolt
目的PET显像用于研究血管紧张素Ⅱ 1型受体（AT（1）R）。本研究的目的是调查急性和慢性暴露于血管紧张素转换酶抑制剂（ACEI）对AT（1）R在犬kidney.Methods动物成像基线，急性静脉ACEI治疗后，慢性暴露于口服ACEI 2周后。结果慢性ACEI治疗组大鼠肾皮质AT（1）R结合（K（i）表达）明显增加（p < 0.05）。AT（1）R密度（B（max））的体外测量也显示在离体肾小球中AT（1）R显著增加（p < 0.05）。血浆肾素活性增加，但血管紧张素II（Ang II）和血管紧张素II/血管紧张素I的比例表现出弱相关性与慢性ACEI治疗，符合血管紧张素II逃逸phenomenon.Conclusions这项研究揭示，第一次，慢性ACEI治疗增加AT（1）R结合在体内的狗肾皮质。
Purpose PET imaging has been recently introduced for investigating the type 1 angiotensin II receptor (AT(1)R) in vivo. The goal of the present study was to investigate the effects of acute and chronic exposure to angiotensin converting enzyme inhibitors (ACEI) on the AT(1)R in the dog kidney.Methods Animals were imaged at baseline, after acute intravenous ACEI treatment and after a chronic 2-week exposure to an oral ACEI. Control animals were imaged at identical time points in the absence of ACEI treatment.Results In vivo AT(1)R binding expressed by K (i) was increased in the renal cortex by chronic ACEI treatment (p < 0.05). In vitro measurements of AT(1)R density (B (max)) also revealed significant increases in AT(1)R in isolated glomeruli (p < 0.05). Plasma renin activity was increased, but angiotensin II (Ang II) and the Ang II/Ang I ratio showed a weak correlation with chronic ACEI treatment, consistent with an Ang II escape phenomenon.Conclusions This study reveals, for the first time, that chronic ACEI treatment increases AT(1)R binding in vivo in the dog renal cortex.