Preserved pancreatic β-cell development and function in mice lacking the insulin receptor-related receptor
Preserved pancreatic β-cell development and function in mice lacking the insulin receptor-related receptor
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DOI：
10.1128/mcb.21.16.5624-5630.2001
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发表时间：
2001-08-01
影响因子：
5.3
通讯作者：
Accili, D
中科院分区：
文献类型：
--
作者：
Kitamura, T;Kido, Y;Accili, D
Receptors of the insulin/insulinlike growth factor (IGF) family have been implicated in the regulation of pancreatic beta -cell growth and insulin secretion. The insulin receptor-related receptor (IRR) is an orphan receptor of the insulin receptor gene (Ir) subfamily. It is expressed at considerably higher levels in beta cells than either insulin or IGF-I receptors, and it has been shown to engage in heterodimer formation with insulin or IGF-1 receptors. To address whether IRR plays a physiologic role in beta -cell development and regulation of insulin secretion, we have characterized mice lacking IRR and generated a combined knockout of Ir and Irr. We report that islet morphology, beta -cell mass, and secretory function are not affected in IRR-deficient mice. Moreover, lack of IRR does not impair compensatory beta -cell hyperplasia in insulin-resistant Ir+/- mice, nor does it affect beta -cell development and function in Ir-/- mice. We conclude that glucose-stimulated insulin secretion and embryonic beta -cell development occur normally in mice lacking Irr.
