Controlled Depolymerization: Stimuli-Responsive Self-Immolative Polymers
Controlled Depolymerization: Stimuli-Responsive Self-Immolative Polymers
复制标题
DOI：
10.1021/ma300817v
复制
发表时间：
2012-09-25
期刊：
影响因子：
5.5
通讯作者：
Boydston, Andrew J.
中科院分区：
文献类型：
--
作者：
Peterson, Gregory I.;Larsen, Michael B.;Boydston, Andrew J.
自分解聚合物（SIPs）是一种独特的大分子，能够对多种类型的环境影响做出反应，并产生放大的响应输出。当安装在SIP链末端的触发部分被它们相应的刺激物激活时，自发的头到尾解聚反应，通常涉及小分子的多位点释放。SIP设计在其每个功能组件中已经发展了高度的模块化，从而实现了广泛的实用程序和应用程序驱动的调优。在这个角度来看，我们总结和讨论在这个新兴的研究领域的最新进展，包括（i）不同类型的SIP的合成，（ii）触发部分的设计和评估，（iii）解聚机制和动力学，（iv）SIP的应用，和（v）展望和面临的挑战领域。
Self-immolative polymers (SIPs) are unique macromolecules that are able to react to multiple types of environmental influences by giving amplified response outputs. When triggering moieties installed at SIP chain ends are activated by their corresponding stimuli, a spontaneous head-to-tail depolymerization ensues, often involving multitopic release of small molecules. SIP designs have evolved a high degree of modularity in each of their functional components, enabling a broad range of utility and applications-driven tuning. In this Perspective, we summarize and discuss recent progress in this nascent area of research, including (i) synthesis of different types of SIPs, (ii) design and evaluation of triggering moieties, (iii) depolymerization mechanisms and kinetics, (iv) applications of SIPs, and (v) outlook and challenges facing the field.