SPECTOMYCINS, NEW ANTIBACTERIAL COMPOUNDS PRODUCED BY STREPTOMYCES-SPECTABILIS - ISOLATION, STRUCTURES, AND BIOSYNTHESIS
SPECTOMYCINS, NEW ANTIBACTERIAL COMPOUNDS PRODUCED BY STREPTOMYCES-SPECTABILIS - ISOLATION, STRUCTURES, AND BIOSYNTHESIS
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DOI：
10.7164/antibiotics.47.1425
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发表时间：
1994-12-01
影响因子：
3.3
通讯作者：
RINEHART, KL
中科院分区：
文献类型：
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作者：
STALEY, AL;RINEHART, KL
从特殊链霉菌的改良培养液中分离出3种新的四氢蒽类抗生素。新化合物A1， A2和B1以单体（C20H20O7, Al; C19H18O7, A2）和对称二聚体（C38H34O14; B1）形式存在。只有spectomycin B1对革兰氏阳性微生物具有中等活性。本文报道了这些化合物的结构解析和生物合成来源。
Three new tetrahydroanthracene antibiotics have been isolated from modified culture broths of Streptomyces spectabilis. The new compounds, spectomycins A1, A2 and B1, exist as monomeric (C20H20O7, Al; C19H18O7, A2) and as symmetrical dimeric (C38H34O14; B1) forms. Only spectomycin B1 has moderate activity against Gram-positive microorganisms. We report here the structure elucidation and biosynthetic origin of these compounds.