Chemotaxis during neural crest migration.
Chemotaxis during neural crest migration.
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DOI：
10.1016/j.semcdb.2016.01.031
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发表时间：
2016-07
影响因子：
7.3
通讯作者：
Adam Shellard;R. Mayor
中科院分区：
文献类型：
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作者：
Adam Shellard;R. Mayor
趋化性是指细胞沿其梯度向外部可溶性因子沿着定向迁移。这是一个由许多不同类型的细胞在发育过程中用于组织组织和胚胎结构形成以及癌症转移等疾病的过程。神经嵴（NC）是一种多能性、高度迁移的细胞群，对一系列组织有贡献。据推测，NC迁移，至少部分，是依赖于趋化信号。这篇综述将探讨目前的证据，建议NC细胞的趋化因子，并概述了NC对它们的趋化反应的机制。
Chemotaxis refers to the directional migration of cells towards external, soluble factors along their gradients. It is a process that is used by many different cell types during development for tissue organisation and the formation of embryonic structures, as well as disease like cancer metastasis. The neural crest (NC) is a multipotent, highly migratory cell population that contribute to a range of tissues. It has been hypothesised that NC migration, at least in part, is reliant on chemotactic signals. This review will explore the current evidence for proposed chemoattractants of NC cells, and outline mechanisms for the chemotactic response of the NC to them.