Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity
Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity
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DOI：
10.1093/brain/awh199
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发表时间：
2004-08-01
期刊：
影响因子：
14.5
通讯作者：
Minshew, NJ
中科院分区：
文献类型：
--
作者：
Just, MA;Cherkassky, VL;Minshew, NJ
一组高功能自闭症患者在句子理解过程中使用功能性MRI测量大脑激活，并将结果与言语智商匹配的对照组进行比较。两组在两个关键语言区域的激活分布不同。自闭症组在韦尼克（左颞上外侧）区产生的激活比对照组多，在布罗卡（左额下回）区产生的激活比对照组少。此外，功能连接，即同步或激活的时间序列之间的相关性的程度，各个参与皮层区域始终低于自闭症患者比控制参与者。这些研究结果表明，自闭症语言障碍的神经基础需要较低程度的信息整合和同步的大规模皮层网络的语言处理。这篇文章提出了一个理论上的研究结果，与自闭症的神经生物学基础连接不足。
The brain activation of a group of high-functioning autistic participants was measured using functional MRI during sentence comprehension and the results compared with those of a Verbal IQ-matched control group. The groups differed in the distribution of activation in two of the key language areas. The autism group produced reliably more activation than the control group in Wernicke's (left laterosuperior temporal) area and reliably less activation than the control group in Broca's (left inferior frontal gyrus) area. Furthermore, the functional connectivity, i.e. the degree of synchronization or correlation of the time series of the activation, between the various participating cortical areas was consistently lower for the autistic than the control participants. These findings suggest that the neural basis of disordered language in autism entails a lower degree of information integration and synchronization across the large-scale cortical network for language processing. The article presents a theoretical account of the findings, related to neurobiological foundations of underconnectivity in autism.