Changes in interhemispheric inhibition from active to resting primary motor cortex during a fine-motor manipulation task
Changes in interhemispheric inhibition from active to resting primary motor cortex during a fine-motor manipulation task
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DOI：
10.1152/jn.00888.2011
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发表时间：
2012-06-01
影响因子：
2.5
通讯作者：
Funase, Kozo
中科院分区：
文献类型：
--
作者：
Morishita, Takuya;Uehara, Kazumasa;Funase, Kozo
Morishita T，Uehara K，Funase K，在精细运动操作任务中，大脑半球间抑制从活跃的初级运动皮质转变为静止的初级运动皮质。神经生理学杂志107：3086-3094,2012。2012年3月14日首次出版；DOI：10.1152/jn.00888.2011。-在10名右撇子受试者中，研究了感觉运动任务的执行对从活跃的初级运动皮质(M1)到静止的M1所诱发的大脑半球间抑制的影响。经颅磁刺激(TMS)在静息状态(RT)-第一骨间背侧(FDI)产生运动诱发电位(MEP)。对于配对TMS范式，向RT-M1提供条件刺激(CS)，其强度从左侧MEP静息运动阈值的0.6倍调整到1.4倍-fDi，分0.2步进行。将测试刺激传递给LT-M1，并调整其强度，以在任务条件下引起RT-FDI中类似的MEP幅度。刺激间期固定为10ms。作为感觉运动任务，采用了精细运动操作(FM)任务(使用筷子拾起、运输和释放玻璃球)。此外，还执行了等长外展(IA)任务作为对照任务。这些任务是用左手完成的。与IA任务相比，在FM任务中观察到的从活动期到静止期的IHI显著增加，并且这一效应不依赖于CS在活跃的LT-fDi中诱发的MEP幅度。目前的发现表明，在FM任务中观察到的从活动期到静止期的IHI增加与同侧皮质内抑制回路的活动减少有关，正如我们之前所报道的那样。
Morishita T, Uehara K, Funase K. Changes in interhemispheric inhibition from active to resting primary motor cortex during a fine-motor manipulation task. J Neurophysiol 107: 3086-3094, 2012. First published March 14, 2012; doi:10.1152/jn.00888.2011.-The effect of performance of a sensorimotor task on the interhemispheric inhibition (IHI) induced from the active primary motor cortex (M1) to the resting M1 was examined in 10 right-handed subjects. Transcranial magnetic stimulation (TMS) was performed to produce motor evoked potentials (MEP) in the resting right (Rt)-first dorsal interosseous (FDI). For the paired-TMS paradigm, a conditioning stimulus (CS) was delivered to the Rt-M1, and its intensity was adjusted from 0.6 to 1.4 times the resting motor threshold of the MEP in the left (Lt)-FDI in 0.2 steps. The test stimulus was delivered to the Lt-M1, and its intensity was adjusted to evoke similar MEP amplitudes in the Rt-FDI among the task conditions. The interstimulus interval was fixed at 10 ms. As a sensorimotor task, a fine-motor manipulation (FM) task (using chopsticks to pick up, transport, and release glass balls) was adopted. In addition, an isometric abduction (IA) task was also performed as a control task. These tasks were carried out with the left hand. The IHI from the active to the resting M1 observed during the FM task was markedly increased compared with that induced during the IA task, and this effect was not dependent on the MEP amplitude evoked in the active Lt-FDI by the CS. The present findings suggest that the increased IHI from the active to the resting M1 observed during the FM task was linked to reductions in the activity of the ipsilateral intracortical inhibitory circuit, as we reported previously.