Activatable Persistent Luminescence from Porphyrin Derivatives and Supramolecular Probes with Imaging-Modality Transformable Characteristics for Improved Biological Applications**
Activatable Persistent Luminescence from Porphyrin Derivatives and Supramolecular Probes with Imaging-Modality Transformable Characteristics for Improved Biological Applications**
复制标题
卟啉衍生物和超分子探针的可激活持续发光，具有成像模态可转换特性，可改善生物应用
DOI：
10.1002/anie.202116174
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发表时间：
2022-02-03
影响因子：
16.6
通讯作者：
Ding, Dan
中科院分区：
文献类型：
--
作者：
Duan, Xingchen;Zhang, Guo-Qiang;Ding, Dan
无激发光和组织自身荧光干扰的持续发光在生物应用中具有很大的前景，但受到具有长波发射和良好临床潜力的现有材料的限制。在这里，我们报道了卟啉衍生物在停止激发光或与过氧亚硝酸盐相互作用后可以发出超过60分钟的近红外持续发光。证明了乙烯键连续氧化的合理机理。构建了一种具有β -片结构的超分子探针，以增强肿瘤靶向能力和光声和持续发光信号。这种探针具有从光声成像到持续发光成像的光触发功能转换，允许先进的图像引导癌症手术。此外，过氧亚硝酸盐激活的持续发光超分子探针也可以快速准确地筛选免疫原性细胞死亡药物。
Persistent luminescence without excitation light and tissue autofluorescence interference holds great promise for biological applications, but is limited by available materials with long-wavelength emission and excellent clinical potential. Here, we report that porphyrin derivatives can emit near-infrared persistent luminescence over 60 min after cessation of excitation light or on interaction with peroxynitrite. A plausible mechanism of the successive oxidation of vinylene bonds was demonstrated. A supramolecular probe with a beta-sheet structure was constructed to enhance the tumor targeting ability and the photoacoustic and persistent luminescence signals. Such probes featuring light-triggered function transformation from photoacoustic imaging to persistent luminescence imaging permit advanced image-guided cancer surgery. Furthermore, peroxynitrite-activated persistent luminescence of the supramolecular probe also enables rapid and precise screening of immunogenic cell death drugs.