Polymer-Assisted Cartilage and Tendon Repair

Polymer-Assisted Cartilage and Tendon Repair
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DOI：
10.1007/978-3-319-13266-2_13
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发表时间：
2015
期刊：
--
影响因子：
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通讯作者：
G. Schulze-Tanzil
G. Schulze-Tanzil
中科院分区：
其他
文献类型：
--
作者：
G. Schulze-Tanzil

文献摘要

相似文献

外伤性软骨损伤的内在修复一般较差；以类似的方式，肌腱断裂的修复可能会带来意想不到的结果，如疤痕形成和生物力学组织特性的改变。因此，利用组织工程（TE）技术的进一步研究应该有助于减少愈合时间，恢复软骨和肌腱在损伤后的自然结构。天然和合成聚合物在软骨和肌腱组织工程中起着重要的人工基质作用。一些基于te的治疗方法已经进入临床实践。本章讨论了软骨和肌腱的哪些特性必须解决的合成聚合物用于TE，哪些种类的聚合物已经测试到目前为止，以及哪些未满足的医疗需求仍然为软骨和肌腱TE。重建肌腱-骨界面以实现稳定的聚合物基TE肌腱重建策略的重要问题也将被讨论。te辅助软骨和肌腱重建的未来发展方向是开发仿生聚合物支架，充分恢复组织地带性，实现种植体的整合和机械能力，最后但不是最不重要的是建立临床应用的一步策略。此外，聚合物可用于帮助在培养和预培养过程中实现更快的软骨细胞和肌腱细胞数量的扩增。
Intrinsic repair of traumatic cartilage injuries is generally poor; in a similar manner, the repair of ruptured tendons can be associated with unwanted results such as scar formation and altered biomechanical tissue properties. Therefore, further research utilizing tissue engineering (TE) techniques should help to reduce healing times and to restore natural structure of cartilage and tendon in response to injury. Natural and synthetic polymers play a pivotal role as artificial matrices for cartilage and tendon tissue engineering. Some TE-based therapeutical approaches have already found entry in the clinical praxis. This chapter discusses which peculiarities of cartilage and tendon have to be addressed for the use of synthetic polymers for TE, which kinds of polymers have been tested so far, and which unmet medical needs remain for cartilage and tendon TE. The important issue of reestablishing the tendon-to-bone interface for stable polymer-based TE tendon reconstruction strategies will also be discussed. Future directions for TE-assisted cartilage and tendon reconstruction are to develop biomimetic polymer scaffolds, to fully restore tissue zonality and achieve implant integration, mechanocompetence, and last but not least, to establish one step strategies for clinical application. Additionally, polymers could be used to help achieve more rapid expansion of chondrocyte and tenocyte numbers in culture, and for preculturing procedures.