Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo
Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo
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DOI：
10.1172/jci13997
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发表时间：
2002-01-01
影响因子：
15.9
通讯作者：
Baenziger, JU
中科院分区：
文献类型：
--
作者：
Mi, YL;Shapiro, SD;Baenziger, JU
促黄体激素（LH）通过调节雌激素和孕激素的产生来指导排卵和着床。我们已经证明LH的循环半衰期由Man/GalNAc-4-SO 4受体控制，该受体结合LH寡糖上的GalNAc-4-SO 4。短的半衰期与垂体中LH的间歇性释放一起解释了循环中LH的脉动式上升和下降。Man/GalNAc-4-SO 4受体的完全基因切除导致子宫内死亡。杂合子雌性小鼠从循环中清除LH的速度更慢，并且由于着床率降低而具有较小的窝仔。这种减少是完全可以纠正的外源性孕酮和雌激素，表明LH清除率是至关重要的生产足够的孕酮和雌激素植入。因此，Man/GalNAc-4-SO 4受体调节雌性的内分泌状态，并且对于胚胎发育的早期事件是必需的。
Lutropin (LH) directs ovulation and implantation by regulating the production of estrogen and progesterone. We have shown that the circulatory half-life of LH is controlled by the Man/GalNAc-4-SO4 receptor, which binds GalNAc-4-SO4 on LH oligosaccharides. The short half-life in conjunction with episodic release of LH from the pituitary accounts for the pulsatile rise and fall in circulating LH. Complete genetic ablation of the Man/GalNAc-4-SO4 receptor results in death in utero. Heterozygous female mice clear LH from the circulation more slowly and have smaller litters due to a reduction in the rate of implantation. This reduction is fully correctable by exogenous progesterone and estrogen, indicating that the rate of LH clearance is critical for the production of sufficient progesterone and estrogen for implantation. Thus, the Man/GalNAc-4-SO4 receptor regulates the endocrinological status of the female and is essential for an early event in embryonic development.