Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education
Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education
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DOI：
10.1038/s41598-020-64883-8
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发表时间：
2020-05-14
影响因子：
4.6
通讯作者：
Silventoinen, Karri
中科院分区：
文献类型：
--
作者：
Jelenkovic, Aline;Sund, Reijo;Silventoinen, Karri
遗传因素解释了人类身高变化的大部分，但社会经济类别之间也发现了平均身高的差异，这表明可能受到环境的影响。通过利用一个经典的双胞胎设计，可以分解成遗传和环境因素的高度的变化，我们测试的假设，即环境的高度变化是更大的受教育程度较低的父母的后代。来自29个队列的双胞胎数据，包括65，978对完整的双胞胎对，其中包括1至69岁的身高和父母教育信息，这些数据被合并，以便在不同年龄和三个地理文化区域（欧洲，北美和澳大利亚以及东亚）进行分析。父母的教育程度大多与子女的身高呈正相关，在童年中期和青春期以后有显著的相关性。在方差分解模型中，身高的遗传和环境方差分量与父母的教育程度没有表现出一致的关系。一个随机效应荟萃回归分析的总体水平的数据显示，更大的共享环境变化的高度在低父母教育程度的家庭的趋势。总之，在我们来自地球仪的双胞胎队列的非常大的数据集中，这些结果仅为研究假设提供了弱证据。
Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.