Efficiency of information transmission by retinal ganglion cells
Efficiency of information transmission by retinal ganglion cells
复制标题
DOI：
10.1016/j.cub.2004.08.060
复制
发表时间：
2004-09-07
期刊：
影响因子：
9.2
通讯作者：
Freed, MA
中科院分区：
文献类型：
--
作者：
Koch, K;McLean, J;Freed, MA
背景：不同类型的视网膜神经节细胞向大脑传递不同的信息。信息以尖峰模式的形式出现，每秒可能出现的模式数量决定了编码能力。我们问，如果不同的神经节细胞类型同样有效地利用他们的编码能力，或是否效率取决于消息criminated.Results：我们记录的棘波列车从视网膜神经节细胞在豚鼠视网膜的体外制备。通过计算，对于观察到的尖峰速率，每秒可能的尖峰模式的数量，我们计算了编码容量，并通过计算模式的实际数量，我们估计了信息率。具有“活跃”反应的细胞，即，高发射速率，以及一般消息以高速率（21 +/-9比特s（-1））传输信息。具有“迟缓”反应的细胞，即，较低的激发速率和特定的消息（运动方向、局部边缘）以较低的速率（13 +/-7比特s（-1））传输信息。然而，对于每一种类型的神经节细胞，信息速率大约是编码能力的三分之一。对于每个神经节细胞，信息率非常接近（在4%以内）根据泊松噪声和细胞实际时间调制率预测的信息率。结论：不同的信息以相似的效率传输。效率受到时间相关性的限制，但是相关性对于在存在不可约噪声的情况下改进解码可能是必不可少的。
Background: Different types of retinal ganglion cells convey different messages to the brain. Messages are in the form of spike patterns, and the number of possible patterns per second sets the coding capacity. We asked if different ganglion cell types make equally efficient use of their coding capacity or whether efficiency depends on the message conveyed.Results: We recorded spike trains from retinal ganglion cells in an in vitro preparation of the guinea pig retina. By calculating, for the observed spike rate, the number of possible spike patterns per second, we calculated coding capacity, and by counting the actual number of patterns, we estimated information rate. Cells with "brisk" responses, i.e., high firing rates, and a general message transmitted information at high rates (21 +/- 9 bits s(-1)). Cells with "sluggish" responses, i.e., lower firing rates, and specific messages (direction of motion, local-edge) transmitted information at lower rates (13 +/- 7 bits s(-1)). Yet, for every type of ganglion cell examined, the information rate was about one-third of coding capacity. For every ganglion cell, information rate was very close (within 4%) to that predicted from Poisson noise and the cell's actual time-modulated rate.Conclusions: Different messages are transmitted with similar efficiency. Efficiency is limited by temporal correlations, but correlations may be essential to improve decoding in the presence of irreducible noise.