A panel of four decreased serum microRNAs as a novel biomarker for early Parkinson's disease
A panel of four decreased serum microRNAs as a novel biomarker for early Parkinson's disease
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DOI：
10.3109/1354750x.2015.1118544
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发表时间：
2016-02-17
期刊：
影响因子：
2.6
通讯作者：
Zhang, Chen-Yu
中科院分区：
文献类型：
--
作者：
Dong, Hui;Wang, Cheng;Zhang, Chen-Yu
内容：目的：探讨循环microRNAs（microRNAs，miRNAs）作为帕金森病（Parkinson's disease，PD）诊断和分期的新生物标志物的可能性。材料和方法：应用Solexa测序技术和实时定量PCR技术，筛选和验证PD患者血清中miRNAs的改变。与对照组相比，PD患者的血清miR-141、miR-214、miR-146 b-5 p和miR-193 a-3 p显著降低。此外，4-miRNA面板能够区分HY阶段1和2 PD patients from controls.Discussion and conclusion：这四种血清miRNA可能代表PD早期检测的新生物标志物。
Context: Sensitive, non-invasive biomarkers that facilitate Parkinson's disease (PD) detection and stage assignment are currently unavailable.Objective: The objective of this study is to investigate the potential of circulating microRNAs (miRNAs) as novel biomarkers for PD.Materials and methods: Solexa sequencing technology and quantitative real-time PCR were applied to screen and verify altered serum miRNAs in PD patients.Results: Serum miR-141, miR-214, miR-146b-5p, and miR-193a-3p were decreased significantly in PD patients compared with controls. Furthermore, the 4-miRNA panel enabled the differentiation of HY stage 1 and 2 PD patients from controls.Discussion and conclusion: The four serum miRNAs may represent novel biomarkers for the early detection of PD.