Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure
Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure
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DOI：
10.1023/a:1025490017780
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发表时间：
2003-09-01
影响因子：
4.3
通讯作者：
Steinberg, SF
中科院分区：
文献类型：
--
作者：
Sabri, A;Steinberg, SF
蛋白激酶C同种型包括结构上相关的丝氨酸/苏氨酸激酶家族，其被通过磷脂酶C的受体依赖性活化形成的第二信使分子活化。心肌细胞共表达多种蛋白激酶C亚型，在适应性和适应不良心脏反应中发挥关键作用。这一章集中在结构特点，激活模式，和不同的细胞行动的个别PKC亚型在心脏。特别强调的进展，来自PKC亚型过表达或基因缺失的小鼠的分子模型的研究。最近的研究区分新的PKC亚型（PKC δ和PKC β）的功能特性，从彼此，并从传统的PKC亚型的行动，并建议这些蛋白质可能发挥特别重要的作用，导致心脏生长和/或心脏保护的途径也被认为是。
Protein kinase C isoforms comprise a family of structurally related serine/threonine kinases that are activated by second messenger molecules formed via receptor-dependent activation of phospholipase C. Cardiomyocytes co-express multiple protein kinase C isoforms which play key roles in a spectrum of adaptive and maladaptive cardiac responses. This chapter focuses on the structural features, modes of activation, and distinct cellular actions of individual PKC isoforms in the heart. Particular emphasis is placed on progress that comes from studies in molecular models of PKC isoform overexpression or gene deletion in mice. Recent studies that distinguish the functional properties of novel PKC isoforms (PKCdelta and PKCepsilon) from each other, and from the actions of the conventional PKC isoforms, and suggest that these proteins may play a particularly significant role in pathways leading to cardiac growth and/or cardioprotection also are considered.