Inhibiting intracellular signalling as a strategy for cancer chemoprevention.
Inhibiting intracellular signalling as a strategy for cancer chemoprevention.
复制标题
抑制细胞内信号传导作为癌症化学预防的策略。
DOI：
10.1016/0959-8049(94)90473-1
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Alberts,DS
中科院分区：
文献类型：
--
作者：
Powis,G;Alberts,DS
介导生长因子和癌基因对细胞生长和转化的影响的细胞内信号传导途径为开发化学预防剂提供了潜在的靶点，该化学预防剂可防止癌前细胞向浸润性癌症的进展。作用于信号传导靶点的药剂预期是细胞抑制剂而不是细胞毒性剂。许多现有的化学预防剂在其性质中表现出对细胞内信号传导酶的抑制。这种活性可能至少部分地解释了它们的化学预防特性。
The intracellular signalling pathways that mediate the effects of growth factors and oncogenes on cell growth and transformation offer potential targets for the development of chemopreventive agents that prevent the progression of premalignant cells to invasive cancer. Agents acting on signalling targets would be expected to be cytostatic rather than cytotoxic agents. A number of existing chemopreventive agents exhibit, among their properties, inhibition of intracellular signalling enzymes. It is possible that this activity accounts, at least in part, for their chemopreventive properties.