Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations
Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations
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DOI：
10.1177/1470320312450599
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发表时间：
2013-03-01
影响因子：
2.9
通讯作者：
Niu, Wenquan
中科院分区：
文献类型：
--
作者：
Li, Yuqiong;Li, Xiaobo;Niu, Wenquan
背景与目的：血管紧张素II受体1型(AGTR1)基因A1166C多态性与冠心病的关系已有多项研究，但结果仍存在争议。方法与结果：对PubMed、万方和中国国家知识基础设施(CNKI)数据库进行全面检索，检索时间为2012年1月前。数据和研究质量评定一式两份。分析了22项研究，总计3502名CAD患者和3071名对照。总体而言，携带1166C等位基因的个体与携带1166AA基因的个体相比，患冠心病的风险显著增加(优势比(OR)=1.63；95%可信区间(CI)：1.26~2.1；P=60岁)。结论：AGTR1基因A1166C多态可能是中国人群冠心病发病的遗传标志，特别是在北方和老年人群的研究中。
Background and objective: Many studies have examined the association between the angiotensin II receptor, type 1 (AGTR1) gene A1166C polymorphism and coronary artery disease (CAD); the results, however, remain controversial. Given the accumulation of data, we conducted a meta-analysis of published studies on this association in Chinese.Methods and results: A comprehensive search of PubMed, Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases was conducted before January 2012. Data and study quality were assessed in duplicate. Twenty-two studies totaling 3502 CAD patients and 3071 controls were analyzed. Overall, individuals carrying 1166C allele had a remarkably increased risk of CAD compared with those with 1166AA genotype (odds ratio (OR)=1.63; 95% confidence interval (CI): 1.26-2.1; P= 60 years. Differences in the diagnosis of CAD and source of controls might be potential sources of between-study heterogeneity.Conclusions: Our findings provided strong evidence that AGTR1 gene A1166C polymorphism might be a genetic marker for the development of CAD in Chinese populations, especially in the context of studies with northern and older subjects.