The emerging role of splicing factors in cancer
The emerging role of splicing factors in cancer
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DOI：
10.1038/embor.2008.189
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发表时间：
2008-11-01
期刊：
影响因子：
7.7
通讯作者：
Carmo-Fonseca, Maria
中科院分区：
文献类型：
--
作者：
Grosso, Ana Rita;Martins, Sandra;Carmo-Fonseca, Maria
全球序列和微阵列数据分析的最新进展揭示了人类转录组的日益复杂。选择性剪接产生了巨大多样性的转录变体，剪接调控网络的破坏正在成为包括癌症在内的各种疾病的重要贡献者。目前建立健康和疾病中产生的转录本的动态谱系的努力表明，许多与癌症相关的选择性剪接事件发生在受影响基因没有突变的情况下。越来越多的证据表明，剪接因子表达的变化与癌症的发展、进展和治疗反应有关。在这里，我们讨论了最近癌症和剪接调控中涉及的蛋白质表达变化之间的联系如何使剪接机制成为抗癌治疗的潜在靶点。
Recent progress in global sequence and microarray data analysis has revealed the increasing complexity of the human transcriptome. Alternative splicing generates a huge diversity of transcript variants and disruption of splicing regulatory networks is emerging as an important contributor to various diseases, including cancer. Current efforts to establish the dynamic repertoire of transcripts that are generated in health and disease are showing that many cancer-associated alternative-splicing events occur in the absence of mutations in the affected genes. A growing body of evidence reveals changes in splicing-factor expression that correlate with cancer development, progression and response to therapy. Here, we discuss how recent links between cancer and altered expression of proteins implicated in splicing regulation are bringing the splicing machinery to the fore as a potential target for anticancer treatment.