Ulcerative colitis.
Ulcerative colitis.
复制标题
溃疡性结肠炎。
DOI：
10.1016/s0140-6736(16)32126-2
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发表时间：
2017-04-29
期刊：
影响因子：
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通讯作者：
Colombel JF
中科院分区：
文献类型：
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作者：
Ungaro R;Mehandru S;Allen PB;Peyrin-Biroulet L;Colombel JF
溃疡性结肠炎是一种影响结肠的慢性炎症性疾病，其发病率在世界范围内呈上升趋势。其发病机制是多因素的，涉及遗传易感性、上皮屏障缺陷、免疫反应失调和环境因素。溃疡性结肠炎患者的粘膜炎症始于直肠，可持续延伸至结肠近端。溃疡性结肠炎通常表现为带血腹泻，可通过结肠镜检查和组织学检查诊断。治疗的目的是诱导并维持缓解，定义为症状的缓解和内镜下愈合。溃疡性结肠炎的治疗包括5-氨基水杨酸类药物、类固醇和免疫抑制剂。一些难治性疾病或治疗结肠肿瘤的患者可能需要结肠切除术。溃疡性结肠炎的治疗手段正在不断扩大，具有新靶点的药物数量将在未来几年迅速增加。
Ulcerative colitis is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide. The pathogenesis is multifactorial, involving genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors. Patients with ulcerative colitis have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon. Ulcerative colitis usually presents with bloody diarrhoea and is diagnosed by colonoscopy and histological findings. The aim of management is to induce and then maintain remission, defined as resolution of symptoms and endoscopic healing. Treatments for ulcerative colitis include 5-aminosalicylic acid drugs, steroids, and immunosuppressants. Some patients can require colectomy for medically refractory disease or to treat colonic neoplasia. The therapeutic armamentarium for ulcerative colitis is expanding, and the number of drugs with new targets will rapidly increase in coming years.