Biocompatibility and biofouling of MEMS drug delivery devices
Biocompatibility and biofouling of MEMS drug delivery devices
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DOI：
10.1016/s0142-9612(02)00565-3
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发表时间：
2003-05-01
期刊：
影响因子：
14
通讯作者：
Langer, R
中科院分区：
文献类型：
--
作者：
Voskerician, G;Shive, MS;Langer, R
对微加工材料的生物相容性和生物污垢进行了评价。采用笼型植入系统对金属金、氮化硅、二氧化硅、硅和SU-8（TM）光刻胶等MEMS给药组件材料的体内炎症和伤口愈合反应进行评估。将材料放入不锈钢笼中，皮下植入啮齿动物模型。在第4、7、14和21天对笼子内的渗出物进行采样，代表炎症反应的阶段，并测量白细胞浓度（白细胞/mul）。总体而言，在研究期间，这些材料引起的炎症反应与空笼子对照组的炎症反应没有显著差异。通过扫描电镜对4、7、14和21天外植材料的表面细胞密度（巨噬细胞或异物巨细胞，FBGCs）进行测定，这是体内生物污染的一个指标。金、氮化硅、二氧化硅和SU-8（TM）的粘附细胞密度具有可比性，统计学上更低(p
The biocompatibility and biofouling of the microfabrication materials for a MEMS drug delivery device have been evaluated. The in vivo inflammatory and wound healing response of MEMS drug delivery component materials, metallic gold, silicon nitride, silicon dioxide, silicon, and SU-8(TM) photoresist, were evaluated using the cage implant system. Materials, placed into stainless-steel cages, were implanted subcutaneously in a rodent model. Exudates within the cage were sampled at 4, 7, 14, and 21 days, representative of the stages of the inflammatory response, and leukocyte concentrations (leukocytes/mul) were measured. Overall, the inflammatory responses elicited by these materials were not significantly different than those for the empty cage controls over the duration of the study. The material surface cell density (macrophages or foreign body giant cells, FBGCs), an indicator of in vivo biofouling, was determined by scanning electron microscopy of materials explanted at 4, 7, 14, and 21 days. The adherent cellular density of gold, silicon nitride, silicon dioxide, and SU-8(TM) were comparable and statistically less (p