Potassium channel gene associations with joint processing speed and white matter impairments in schizophrenia
Potassium channel gene associations with joint processing speed and white matter impairments in schizophrenia
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DOI：
10.1111/gbb.12372
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发表时间：
2017-06-01
影响因子：
2.5
通讯作者：
Hong, L. E.
中科院分区：
文献类型：
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作者：
Bruce, H. A.;Kochunov, P.;Hong, L. E.
精神分裂症患者在神经心理测试中表现出处理速度下降，在弥散张量成像中表现出白质完整性下降，这两种特征既可遗传又与基因相关，表明可能存在影响这两种特征以及精神分裂症疾病风险的基因。考虑到钾通道在中枢神经系统的信号转导中，特别是在有髓鞘轴突中的重要作用，钾通道基因家族是一个合理的候选基因。我们对363名对照组、194名精神分裂症谱系障碍（SSD）患者和28名具有精神病特征的情感性障碍患者进行了影像学和神经心理学测试，重点研究了大钾通道基因家族成员的推测功能单核苷酸多态性（snp）。然后，我们使用三种表型-处理速度，全脑白质分数各向异性（FA）和精神分裂症谱系诊断进行了三种关联分析。我们提取了在名义P值上显示关联的snp
Patients with schizophrenia show decreased processing speed on neuropsychological testing and decreased white matter integrity as measured by diffusion tensor imaging, two traits shown to be both heritable and genetically associated indicating that there may be genes that influence both traits as well as schizophrenia disease risk. The potassium channel gene family is a reasonable candidate to harbor such a gene given the prominent role potassium channels play in the central nervous system in signal transduction, particularly in myelinated axons. We genotyped members of the large potassium channel gene family focusing on putatively functional single nucleotide polymorphisms (SNPs) in a population of 363 controls, 194 patients with schizophrenia spectrum disorder (SSD) and 28 patients with affective disorders with psychotic features who completed imaging and neuropsychological testing. We then performed three association analyses using three phenotypes - processing speed, whole-brain white matter fractional anisotropy (FA) and schizophrenia spectrum diagnosis. We extracted SNPs showing an association at a nominal P value of