Delayed conception and active and passive smoking
Delayed conception and active and passive smoking
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DOI：
10.1016/s0015-0282(00)01501-6
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发表时间：
2000-10-01
影响因子：
6.7
通讯作者：
Ford, WCL
中科院分区：
文献类型：
--
作者：
Hull, MGR;North, K;Ford, WCL
目的：为了确定是否被动吸烟以及主动吸烟的妇女或吸烟的男性与延迟受孕，调整后的混杂因素。设计：人口研究的夫妇期待一个婴儿。采用逻辑回归分析确定与延迟受孕相关的因素。地点：英国雅芳卫生局地区。患者：所有预期在1991年4月至1992年12月之间分娩的夫妇。干预措施：在妊娠早期使用避孕药。主要结果测量：受孕时间，分类为3年。结果：在校正混杂因素后，妊娠延迟与女性主动吸烟有统计学显著相关（> 6个月的比值比[OR] 1.23 [95% CI 0.98-1.49]，>12个月的比值比[OR] 1.54 [95% CI 1.19-2.01]）和被动吸烟暴露（OR 1.17 [95% CI 1.02-1.37]和1.14 [95% CI 10.92-1.42]）与未暴露于烟草烟雾的女性（参考）相比。男性大量吸烟与延迟受孕独立相关。结论：男性吸烟、女性被动吸烟和主动吸烟与延迟受孕有关。（Fertil Steril（R）2000;74：725-33. (C)美国生殖医学会（American Society for Reproductive Medicine）。
Objective: To determine whether passive as well as active smoking by women or smoking by men is associated with delayed conception, after adjustment for confounding factors.Design: Population study of couples expecting a baby. Logistic regression was performed to identify factors associated with delayed conception.Setting: The Avon Health Authority area, United Kingdom.Patient(s): All couples expected to deliver between April 1991 and December 1992.Intervention(s): Questionnaires administered early in pregnancy.Main Outcome Measure(s): Time taken to conceive, categorized as 3 years.Result(s): After correction for confounding factors, delayed conception was statistically significantly associated with both active smoking by the woman (odds ratio [OR] 1.23 [95% CI 0.98-1.49] for > 6 months and 1.54 [95% CI 1.19-2.01] for >12 months) and her exposure to passive smoking (OR 1.17 [95% CI 1.02-1.37] and 1.14 [95% CI 10.92-1.42]) compared with women with no exposure to tobacco smoke (referent). Heavy smoking by men was independently associated with delayed conception. In active smokers, the effect increased with the number of cigarettes.Conclusion(s): Smoking by men and passive and active smoking by women are associated with delayed conception. (Fertil Steril (R) 2000;74:725-33. (C) 2000 by American Society for Reproductive Medicine.).