Antibody-mediated regulation of cellular immunity and the inflammatory response
Antibody-mediated regulation of cellular immunity and the inflammatory response
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DOI：
10.1016/s1471-4906(03)00228-x
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发表时间：
2003-09-01
影响因子：
16.8
通讯作者：
Pirofski, LA
中科院分区：
文献类型：
--
作者：
Casadevall, A;Pirofski, LA
对于许多病原体而言，人们对抗体介导的免疫 (AMI) 的作用知之甚少，部分原因是可用于确定抗体功效的工具有限。 AN 通常与调理作用、毒素和病毒中和、补体结合和抗体依赖性细胞毒性有关。然而，最近的研究表明 AMI 具有从直接抗菌作用到调节炎症反应的新功能。 AIMI的功效针对一些。病原体依赖于细胞介导的免疫。对 AMI 的作用提出了一种新的解释，即它在感染的早期阶段发挥促炎作用，在宿主-微生物相互作用的后期阶段以及在已建立的免疫环境和/或免疫个体中发挥抗炎作用。
For many pathogens the role of antibody-mediated immunity (AMI) is poorly understood, in part because of the limited tools available to establish antibody efficacy. AN is classically associated with opsonization, toxin and viral neutralization, complement fixation and antibody-dependent cellular cytotoxicity. However, recent studies indicate new functions for AMI ranging from direct antimicrobial action to modulation of the inflammatory response. The efficacy of AIMI against some. pathogens is dependent on cell-mediated immunity. A new interpretation of the role of AMI is proposed whereby it is in proinflammatory the early stages of infection and anti-inflammatory at later stages of the host-microbe interaction and in the setting of established immunity and/or in an immune individual.