Digital phenotyping: An equal opportunity approach to reducing disparities in Alzheimer's disease and related dementia research.
Digital phenotyping: An equal opportunity approach to reducing disparities in Alzheimer's disease and related dementia research.
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DOI：
10.1002/dad2.12495
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发表时间：
2023-10
期刊：
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快速老龄化的世界人口正在推动阿尔茨海默病（AD）和相关痴呆症（ADRD）的伴随增加。然而，科学研究主要集中在澳大利亚、欧盟和北美的白色人口上。因此，在其他人群中对AD的了解不完全。从这个角度来看，我们描述了来自世界三个地区的队列研究的研究努力和挑战：中美洲，东非和东亚。这些队列正在与达沃斯阿尔茨海默氏症协作（DAC），一个全球伙伴关系，汇集了来自世界各地的队列，以促进对AD的理解。每个队列都准备利用移动的设备的广泛使用，将数字表型分析整合到当前的方法中，并缓解地球仪中少数种族和民族AD研究缺乏代表性的问题。除了这三个群体已经使用的方法外，DAC开发了一种数字表型分析方案，可以通过智能手机和/或其他方式远程收集ADRD相关数据。或者在临床中通过平板电脑生成通用数据元素数字数据集，该数据集可以与在每个群组站点收集的附加临床和分子数据相协调，并且当跨群组组合并可访问时，可以提供在世界人口中的种族/民族代表性更强。
A rapidly aging world population is fueling a concomitant increase in Alzheimer's disease (AD) and related dementias (ADRD). Scientific inquiry, however, has largely focused on White populations in Australia, the European Union, and North America. As such, there is an incomplete understanding of AD in other populations. In this perspective, we describe research efforts and challenges of cohort studies from three regions of the world: Central America, East Africa, and East Asia. These cohorts are engaging with the Davos Alzheimer's Collaborative (DAC), a global partnership that brings together cohorts from around the world to advance understanding of AD. Each cohort is poised to leverage the widespread use of mobile devices to integrate digital phenotyping into current methodologies and mitigate the lack of representativeness in AD research of racial and ethnic minorities across the globe. In addition to methods that these three cohorts are already using, DAC has developed a digital phenotyping protocol that can collect ADRD‐related data remotely via smartphone and/or in clinic via a tablet to generate a common data elements digital dataset that can be harmonized with additional clinical and molecular data being collected at each cohort site and when combined across cohorts and made accessible can provide a global data resource that is more racially/ethnically represented of the world population.
DOI：
10.1590/1980-57642021dn15-030005
发表时间：
2021-07
期刊：
Dementia & neuropsychologia
影响因子：
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作者：
Gray WK;Paddick SM;Ogunniyi A;Olakehinde O;Dotchin C;Kissima J;Urasa S;Kisoli A;Rogathi J;Mushi D;Adebiyi A;Haule I;Robinson L;Walker R
通讯作者：
Walker R