THE EXPOSURE ODDS RATIO IN NESTED CASE-CONTROL STUDIES WITH COMPETING RISKS
THE EXPOSURE ODDS RATIO IN NESTED CASE-CONTROL STUDIES WITH COMPETING RISKS
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DOI：
10.1093/oxfordjournals.aje.a114442
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发表时间：
1986-10-01
影响因子：
5
通讯作者：
LOUV, WC
中科院分区：
文献类型：
--
作者：
FLANDERS, WD;LOUV, WC
巢式病例对照研究，也称为双向研究，是队列研究中的病例对照研究。虽然在后续研究中，竞争性风险的扭曲是公认的，但在巢式病例对照研究中，这个问题并没有得到广泛的重视。本文扩展了以前的工作，有关嵌套病例对照研究的竞争风险的偏差。具体而言，扭曲效应的竞争风险的控制选择的三种方法说明。假设比例风险模型，作者推导出当竞争风险不能忽略时优势比偏倚的公式。示例说明了当关注的暴露与死亡或戒断的竞争性原因相关时发生的偏倚程度。
A nested case-control study, also known as an ambidirectional study, is a case-control study within a cohort study. Although distortion by competing risks is well-recognized in follow-up studies, the problem has not been as widely appreciated in nested case-control studies. This paper extends previous work concerning the bias associated with competing risks for nested case-control studies. Specifically, the distorting effect of competing risks is illustrated for three methods of control selection. Assuming the proportional hazards model, the authors derived formulas for the bias of the odds ratio when competing risks cannot be ignored. Examples illustrate the magnitude of bias that occurs when the exposure of interest is associated with competing causes of death or withdrawal.