3D‐Visualised Model of Temperature Distribution in the Brain for Investigation of Brain Cooling Effect
3D‐Visualised Model of Temperature Distribution in the Brain for Investigation of Brain Cooling Effect
复制标题
用于研究大脑冷却效应的大脑温度分布 3D 可视化模型
DOI：
10.1002/ecj.11613
复制
发表时间：
2014
影响因子：
0.3
通讯作者：
H. Wakamatsu
中科院分区：
文献类型：
--
作者：
S. Honma;Yutaka Takagi;H. Wakamatsu
总结
脑低温治疗要求在考虑体温长期变化的情况下，将脑温度控制在适当的范围内。各种数学模型已被用于研究脑温度的控制和冷却能力在低温。在以前的模型中，一个集中参数的半球均匀的温度已被假定为一个简化的大脑模型，而不考虑温度分布。然而，在本研究中，提出了一种新的模型来可视化大脑中的温度分布。该模型具有基于MRI数据的头部器官的近似形状，并且可以很好地反映人体器官的传热系数、代谢产热和热容等属性。该模型有一个伪血流分量，其中任何温度可以设置为初始值在血液流动的起始位置。使用该模型进行模拟，通过将林格氏溶液引入到通向大脑的四条动脉中的任何一条来控制温度。仿真结果表明，不同的冷却效果表现在每个区域的大脑，和温度分布可以知道的应用程序来控制在感兴趣的部分的大脑温度。
SUMMARY
Brain hypothermia requires control of its temperature within an appropriate range, considering the change of body temperature over a long period. Various mathematical models have been used for the study of control and cooling capability of brain temperature in hypothermia. In previous models, a lumped-parameter hemisphere of uniform temperature has been assumed as a simplified brain model without considering the temperature distribution. In the present study, however, a new model is proposed to visualize the temperature distribution in the brain. The model has the approximate shape of the organs in the head based on MRI data, and may well reflect properties such as heat transfer coefficients, metabolic heat production, and heat capacity of human organs. The model has a pseudo-blood-flow component in which any temperature can be set as the initial value at the starting place of blood flow. Simulations using this model were performed with the temperature controlled by the introduction of Ringer's solution into any of the four arteries leading to the brain. The simulation results suggest that the various cooling effects are manifested in every region of brain, and that the temperature distribution can be known for applications to controlling brain temperature in a part of interest.