Exoribonuclease superfamilies: structural analysis and phylogenetic distribution
Exoribonuclease superfamilies: structural analysis and phylogenetic distribution
复制标题
DOI：
10.1093/nar/29.5.1017
复制
发表时间：
2001-03-01
影响因子：
14.9
通讯作者：
Deutscher, MP
中科院分区：
文献类型：
--
作者：
Zuo, YH;Deutscher, MP
核糖核酸外切酶在RNA代谢的各个方面都发挥着重要作用。近年来，生物化学和遗传分析已经鉴定出许多新的RNase，现在很清楚，一个细胞可以包含多个此类酶，在这里，我们分析已知的核糖核酸外切酶的结构和系统发育分布。基于广泛的序列分析和它们的催化性质，所有的核糖核酸外切酶及其同源物被分成六个超家族和各种亚家族。我们确定了共同的图案，可用于表征新发现的核糖核酸外切酶，并根据这些图案，我们纠正了一些以前错误分配的蛋白质。这种分析可以作为一个有用的第一步，为这组酶的命名。
Exoribonucleases play an important role in all aspects of RNA metabolism. Biochemical and genetic analyses in recent years have identified many new RNases and it is now clear that a single cell can contain multiple enzymes of this class, Here, we analyze the structure and phylogenetic distribution of the known exoribonucleases. Based on extensive sequence analysis and on their catalytic properties, all of the exoribonucleases and their homologs have been grouped into six superfamilies and various subfamilies. We identify common motifs that can be used to characterize newly-discovered exoribonucleases, and based on these motifs we correct some previously misassigned proteins. This analysis may serve as a useful first step for developing a nomenclature for this group of enzymes.