MT-45, a new psychoactive substance associated with hearing loss and unconsciousness
MT-45, a new psychoactive substance associated with hearing loss and unconsciousness
复制标题
DOI：
10.3109/15563650.2014.943908
复制
发表时间：
2014-09-01
影响因子：
3.3
通讯作者：
Beck, O.
中科院分区：
文献类型：
--
作者：
Helander, A.;Backberg, M.;Beck, O.
背景资料。MT-45(1-cyclohexyl-4-(1，2-diphenylethyl)piperazine)是20世纪70年代开发的一种阿片类止痛药候选药物，最近作为一种新的精神活性物质被引入“娱乐”药物市场。我们描述了瑞典STRiDA项目中与MT-45相关的非致命性中毒的一系列病例。研究设计。2013年11月至2014年2月，瑞典医院连续出现的连续服用或疑似服用NPS的患者的观察病例系列。病人和方法。血液和尿液样本是从全国各地的急诊科和重症监护病房的醉酒患者身上采集的。NPS的分析采用LC-MS/MS多组分方法。在照顾者咨询毒药信息中心时收集了临床数据，并从医疗记录中检索了这些数据。案件系列。在9起在生物样品中检测到MT-45的中毒中，有4起仅涉及MT-45，其余的病例中发现一种或几种精神活性物质与MT-45一起存在。所有患者都是17-32岁的男性，他们通常表现出阿片类不良症状，如昏迷和呼吸抑制。纳洛酮在几个病例中似乎对MT-45中毒有疗效。三名患者抱怨双侧听力损失，其中一例在两周后仍持续。结论。MT-45应该被添加到越来越多的造成生命威胁的有害核动力源的名单中，并迅速采取行动使其成为受控物质。
Background. MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) is an opioid analgesic drug candidate developed in the 1970s that has recently been introduced as a new psychoactive substance (NPS) on the "recreational" drug market. We describe a case series of non-fatal intoxications associated with MT-45 within the Swedish STRIDA project. Study design. Observational case series of consecutive patients with admitted or suspected intake of NPS presenting to hospitals in Sweden from November 2013 to February 2014. Patients and methods. Blood and urine samples were collected from intoxicated patients presenting to emergency departments and intensive care units over the country. NPS analysis was performed by an LC-MS/MS multi-component method. Clinical data were collected when caregivers consulted the Poisons Information Centre and also retrieved from medical records. Case series. Among nine intoxications where MT-45 was detected in the biological samples, four cases were indicated to only involve MT-45, while one or several psychoactive substances were found along with MT-45 in the others. All patients were men aged 17-32 years and they commonly presented with opioid-like adverse symptoms, such as unconsciousness and respiratory depression. Naloxone appeared to have utility in the treatment of MT-45 intoxication in several cases. Three patients complained of bilateral hearing loss that in one case persisted after two weeks. Conclusion. MT-45 should be added to the growing list of harmful NPS causing life-threatening poisonings, and rapid actions taken to make it a controlled substance.