Enzyme inhibitors and other bioactive compounds from marine actinomycetes
Enzyme inhibitors and other bioactive compounds from marine actinomycetes
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DOI：
10.1007/s10482-004-6544-x
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发表时间：
2005-01-01
影响因子：
2.6
通讯作者：
Imada, C
中科院分区：
文献类型：
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作者：
Imada, C
从海洋环境中收集的各种样品中分离出几种产生酶抑制剂的放线菌，并对其进行了表征。他们中的大多数都生产出了在医药和农业上有用的新化合物。放线菌菌株no。18只在海水中产生针对革兰氏阳性细菌的抗生素，从浅海海水中取样的沉积物中分离出来并对其进行了表征。在60 ~ 110% （v/v）的海水浓度范围内观察到抗生素的产生。因此，生产依赖于海水。研究了从海洋环境中收集的各种放线菌中河豚毒素（TTX）的产生情况。从不同海域分离的10株菌株中，通过高效液相色谱法测定其保留时间，9株产生TTX。据我们所知，这是首次报道海洋环境中产生TTX的放线菌。
Several enzyme-inhibitor-producing actinomycetes were isolated from various samples collected from the marine environment and characterized. Most of them produced novel compounds that are useful in medicine and agriculture. Actinomycete strain no. 18, which produces antibiotics against Gram-positive bacteria only in the presence of seawater, was isolated from sediment sampled from neritic sea water and characterized. The production of antibiotics was observed at seawater concentrations ranging from 60 to 110% (v/v). Thus, the production was seawater-dependent. The production of tetrodotoxin (TTX), known otherwise as puffer fish toxin, was investigated in various actinomycetes collected from the marine environment. Of 10 isolates from various sea areas, 9 produced TTX as judged by their retention times on high-performance liquid chromatography (HPLC). To our knowledge, this is the first report of actinomycetes from the marine environment that produce TTX.