Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase.
Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase.
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DOI：
10.1007/s00430-015-0445-7
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发表时间：
2016-06
影响因子：
5.4
通讯作者：
Schmidt-Chanasit J
中科院分区：
文献类型：
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作者：
Tappe D;Pérez-Girón JV;Zammarchi L;Rissland J;Ferreira DF;Jaenisch T;Gómez-Medina S;Günther S;Bartoloni A;Muñoz-Fontela C;Schmidt-Chanasit J
寨卡病毒是一种新出现的蚊媒黄病毒，目前在太平洋地区和巴西引起大规模流行。从临床来看，寨卡热与登革热相似，但没有登革热严重。尽管临床综合征和实验室诊断程序已被描述，但很少注意到疾病的免疫学及其在患者临床随访中的可能应用。在这里，我们研究了细胞因子在从亚洲、太平洋和巴西返回的旅行者中寨卡热发病机制中的作用。在急性期观察到多功能T细胞激活（Th1、Th2、Th9和Th17反应），其特征是各自的细胞因子水平升高，随后在恢复期下降。
Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, Zika fever resembles dengue fever, but is less severe. Whereas the clinical syndrome and laboratory diagnostic procedures have been described, little attention was paid to the immunology of the disease and its possible use for clinical follow-up of patients. Here, we investigate the role of cytokines in the pathogenesis of Zika fever in travelers returning from Asia, the Pacific, and Brazil. Polyfunctional T cell activation (Th1, Th2, Th9, and Th17 response) was seen during the acute phase characterized by respective cytokine level increases, followed by a decrease in the reconvalescent phase.