STATUS EPILEPTICUS - THE INTERACTION OF EPILEPSY AND ACUTE BRAIN DISEASE
STATUS EPILEPTICUS - THE INTERACTION OF EPILEPSY AND ACUTE BRAIN DISEASE
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DOI：
10.1212/wnl.43.8.1473
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发表时间：
1993-08-01
期刊：
影响因子：
9.9
通讯作者：
HAUSER, WA
中科院分区：
文献类型：
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作者：
BARRY, E;HAUSER, WA
我们确定了217例癫痫持续状态（SE）患者，包括所有病因的所有癫痫发作类型，超过3年。器质性脑疾病和癫痫病史在SE的发展中有显著的相互作用。大多数患者（59%）没有癫痫病史。这些患者更可能有与SE相关的急性沉淀物，并且不太可能有既往脑部疾病。他们年龄较大，更有可能发生全身性惊厥发作，死亡率较高。在88例有癫痫病史的患者中，有较高比例的患者既往有脑损伤，但急性诱因较少。这些患者较年轻，死亡率较低，但在确定的发作前后经常复发SE。严重的急性或既往脑疾病是SE发展的重要因素，即使在有癫痫病史的患者中也是如此。
We identified 217 patients with status epilepticus (SE), including all seizure types from all etiologies, over a 3-year period. There was a significant interaction between organic brain disease and a history of epilepsy in the development of SE. The majority of patients (59%) had no history of epilepsy. These patients were more likely to have acute precipitants associated with SE and less likely to have had prior brain disease. They were older, were more likely to have generalized convulsive seizures, and had a high proportionate mortality. Among the 88 patients with a history of epilepsy, a higher proportion had prior brain insults, but fewer had acute precipitants. These patients were younger and their mortality was low, but they often had recurrent SE before and after the identified episode. Significant acute or prior brain disease is an important factor in the development of SE, even in patients with a history of epilepsy.