Terminal papillary collecting duct reabsorption of water, sodium, and potassium in Psammomys obesus.
Terminal papillary collecting duct reabsorption of water, sodium, and potassium in Psammomys obesus.
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Psammomys obesus 的终末乳头集合管对水、钠和钾的重吸收。
DOI：
10.1152/ajprenal.1980.239.6.f539
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Jamison,RL
中科院分区：
文献类型：
--
作者：
Dobyan,DC;Arrascue,JF;Jamison,RL
微穿刺研究进行了评估的贡献，终末收集管重吸收的水，钠，钾在沙漠啮齿动物，沙鼠obesus。在呋塞米给药前（第I期）和给药后（第II期），在暴露乳头的基部和尖端收集小管液。在第一阶段，菊糖、渗透压摩尔浓度、钠和钾的小管液-血浆（TF/P）比从基部到顶端显著升高; 2.3 +/- 0.8%的过滤水和5.1 +/- 1.7%的过滤钠被集合管重吸收。在第二阶段的水，钠，钾输送到集合管显着增加。虽然TF/P比菊糖，渗透压，钠和钾在第二阶段的基础和尖端比相应的值在第一阶段，所有的比例增加之间的基础和尖端。在第II阶段，暴露的集合管重吸收了约3倍的水（7.4 +/- 1.8%）和2倍的钠（10.1 +/- 3.0%）。这些结果显示了显着的重吸收能力，并建议终末收集管在调节水和钠排泄的肥胖沙鼠起着重要的作用。
Micropuncture studies were performed to assess the contribution of the terminal collecting duct to reabsorption of water, sodium, and potassium in the desert rodent, Psammomys obesus. Tubule fluid was collected at base and tip of the exposed papilla before (period I) and after (period II) administration of furosemide. In period I, a significant rise occurred in tubule fluid-to-plasma (TF/P) ratios of inulin, osmolality, and sodium and potassium from base to tip; 2.3 +/- 0.8% of filtered water and 5.1 +/- 1.7% of filtered sodium were reabsorbed by the collecting duct. In period II water, sodium, and potassium delivery to the collecting duct was significantly increased. Although TF/P ratios for inulin, osmolality, and sodium and potassium were lower at base and tip in period II than corresponding values in period I, all ratios increased between base and tip. Approximately 3 times as much water (7.4 +/- 1.8%) and twice as much sodium (10.1 +/- 3.0%) were reabsorbed by the exposed collecting duct in period II. These results reveal a remarkable reabsorptive capacity and suggest that the terminal collecting duct plays an important role in regulation of water and sodium excretion in Psammomys obesus.