The course of benign partial epilepsy of childhood with centrotemporal spikes: A meta-analysis
The course of benign partial epilepsy of childhood with centrotemporal spikes: A meta-analysis
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DOI：
10.1212/wnl.48.2.430
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发表时间：
1997-02-01
期刊：
影响因子：
9.9
通讯作者：
Brouwer, OF
中科院分区：
文献类型：
--
作者：
Bouma, PAD;Bovenkerk, AC;Brouwer, OF
我们对儿童良性癫痫伴中央颞区棘波（BECT）的研究进行了荟萃分析，以确定是否可以明确地说明临床特征和结局。使用Index Medicus和Medline CD+，我们确定了525篇出版物。在应用国际抗癫痫联盟（ILAE）的BECT标准后，仍有32篇关于2，561例患者的出版物。在对纳入偏倚和相同患者组的多篇出版物进行校正后，纳入了13个队列，共包括794例患者。总缓解比例为0.977;因此，无法确定影响结局的因素。发病年龄3个月~ 14岁，末次发作年龄3 ~ 18岁。按年龄对缓解期儿童的比例进行了Kurtzke生存分析;在年龄较大时，缓解期患者的比例为0.9997。出版物具有高度异质性的方法和人群特征;我们得出结论，目前对BECT的认识主要是通过对有偏倚队列的回顾性研究确定的，BECT作为癫痫综合征本身的一致性可能至少部分是选择偏倚的结果。我们的结论是，早期预测癫痫发作的结果在一个新的病人BECT不能肯定。需要前瞻性的、以人群为基础的研究来描述这种综合征的临床和脑电图特征。
We performed a meta-analysis of studies on benign epilepsy of childhood with centrotemporal spikes (BECT) to ascertain whether clinical characteristics and outcome can be stated unequivocally. Using the Index Medicus and Medline CD+, we identified 525 publications. After applying the criteria of the International League against Epilepsy (ILAE) for BECT, 32 publications on 2,561 patients remained. After correction for inclusion bias and multiple publications on the same patient groups, 13 cohorts, comprising a total of 794 patients, were included. The aggregate proportional remission was 0.977; hence, no factors influencing outcome could be identified. Age at onset ranged From 3 months to 14 years, age at last seizure ranged from 3 to 18 years. A Kurtzke survival analysis of proportions of children in remission by age was performed; at an older age, the proportion of patients in remission was 0.9997. Publications had highly heterogenous methodologies and population characteristics; we conclude that current knowledge on BECT has been determined mainly by retrospective studies of biased cohorts, and that the uniformity per se of BECT as an epileptic syndrome may be, at least in part, a result of selection bias. We conclude that early prediction of seizure outcome in a new patient with BECT can not be given with certainty. Prospective, population-based studies are needed to delineate the clinical and EEG characteristics of this syndrome.