Abnormal Axon Reflex-Mediated Sweating Correlates with High State of Anxiety in Atopic Dermatitis
Abnormal Axon Reflex-Mediated Sweating Correlates with High State of Anxiety in Atopic Dermatitis
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DOI：
10.2332/allergolint.12-oa-0429
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发表时间：
2012-09-01
影响因子：
6.8
通讯作者：
Katayama, Ichiro
中科院分区：
文献类型：
--
作者：
Kijima, Akiko;Murota, Hiroyuki;Katayama, Ichiro
背景：出汗在皮肤稳态中发挥着关键作用，包括抗菌和保湿作用以及皮肤表面 pH 值的调节。在特应性皮炎 (AD) 患者中观察到轴突反射介导 (AXR) 出汗受损。然而，这种异常的促汗轴突反射的机制仍有待揭示。 方法：为了研究这一机制，使用定量促汗轴突反射测试（乙酰胆碱离子电渗疗法）对 AD 患者 (n = 26) 和健康志愿者 (n = 12) 的促汗功能进行了分析。验证了促汗功能与某些背景因素之间的相关性，包括斯皮尔伯格状态特质焦虑量表评分、特应性皮炎严重程度评分 (SCORAD) 评分、循环嗜酸性粒细胞数量、胸腺血清浓度以及活化调节趋化因子和免疫球蛋白 E 放射免疫吸附试验。结果：AD 中的潜伏时间显着延长（p = 0.0352），并且AD 患者的 AXR 出汗量 (mg/0-5 分钟) 显着低于健康对照 (p = 0.0441)。 AD 患者和健康对照者的直接出汗量（毫克/0-5 分钟）相当。未观察到定量催汗轴突反射测试的评估结果与某些背景因素之间存在显着相关性。 AD患者非病变区和病变区的潜伏时间与斯皮尔伯格状态特质焦虑量表中的持续焦虑值以及AXR与SCORAD显示出显着相关性（分别为p = 0.0424、p = 0.0169和p = 0.0523）。 结论：虽然研究对象数量较少，但观察到AD患者的AXR出汗异常。相关分析表明持续焦虑和免疫系统可能与这种异常的促汗功能有关。
Background: Sweating plays a key role in skin homeostasis, including antimicrobial and moisturizing effects, and regulation of skin surface pH. Impaired axon reflex-mediated (AXR) sweating has been observed in patients with atopic dermatitis (AD). However, the mechanism of such abnormal sudomotor axon reflex remains to be revealed.Methods: To investigate this mechanism, sudomotor function was analyzed using a quantitative sudomotor axon reflex test (acetylcholine iontophoresis) in patients with AD (n = 26) and healthy volunteers (n = 12). Correlation between sudomotor function and certain background factors, including Spielberger State Trait Anxiety Inventory score, Severity Scoring of Atopic Dermatitis (SCORAD) score, number of circulating eosinophils, and serum concentrations of thymus and activation-regulated chemokine and immunoglobulin E radioimmunosorbent test, was validated.Results: Latency time was significantly prolonged in AD (p = 0.0352), and AXR sweating volume (mg/0-5 min) was significantly lower in AD patients than in healthy controls (p = 0.0441). Direct sweating volume (mg/0-5 min) was comparable in AD patients and healthy controls. A significant correlation between the evaluation results of quantitative sudomotor axon reflex tests and certain background factors was not observed. The latency time in non-lesioned and lesioned areas for AD patients versus continuous anxiety value in the Spielberger State Trait Anxiety Inventory and the AXR versus SCORAD showed significant correlations (p = 0.0424, p = 0.0169, and p = 0.0523, respectively).Conclusions: Although the number of study subjects was little, abnormal AXR sweating in patients with AD was observed. Correlative analysis suggests possible involvement of continuous anxiety and the immune system in such abnormal sudomotor function.