Tracheal Collapsibility in Healthy Volunteers during Forced Expiration: Assessment with Multidetector CT
Tracheal Collapsibility in Healthy Volunteers during Forced Expiration: Assessment with Multidetector CT
复制标题
DOI：
10.1148/radiol.2521081958
复制
发表时间：
2009-07-01
期刊：
影响因子：
19.7
通讯作者：
Loring, Stephen H.
中科院分区：
文献类型：
--
作者：
Boiselle, Phillip M.;O'Donnell, Carl R.;Loring, Stephen H.
目的：应用多探测器计算机断层扫描评估健康志愿者强迫呼气气管塌陷，并将结果与目前气管软化症的诊断标准进行比较。材料和方法：一个机构审查委员会批准了这项符合hipaa的研究。在获得知情同意后，对51名健康志愿者（年龄范围25-75岁）进行前瞻性研究，这些志愿者的肺活量测量结果正常，没有吸烟史或气管软化症的危险因素。志愿者使用64个检测器行扫描仪成像，在总肺容量和强制呼气时进行肺活量监测，40 ma, 120 kVp， 0.625 mm检测器准直。分别在主动脉弓上方1cm和隆突上方1cm处测量气管横截面积、矢状径和冠状径。计算了气管软化症的呼气塌陷百分比、矢状面和冠状面直径减少以及超过当前诊断标准（> 50%呼气截面积减少）的参与者人数。结果：最终研究人群包括25名男性和26名女性（平均年龄50岁）。气管管腔截面积呼气减少的平均百分比为上气管54.34% +/- 18.6（标准差），下气管56.14% +/- 19.3（标准差）。40名（78%）参与者超过了目前的上气管和/或下气管软化的诊断标准。上、下气管横截面积的减小与矢状径（r分别为0.807和0.688）和冠状径（r分别为0.779和0.751）的减小具有良好的相关性（各相关性P < 0.001）。结论：健康志愿者表现出大范围的强迫呼气气管塌陷，经常超过目前气管软化症的诊断标准。(c) rsna， 2009年
Purpose: To assess forced expiratory tracheal collapsibility in healthy volunteers by using multidetector computed tomography and to compare the results with the current diagnostic criterion for tracheomalacia.Materials and Methods: An institutional review board approved this HIPAA-compliant study. After informed consent was obtained, 51 healthy volunteers (age range, 25-75 years) with normal spirometry results and no history of smoking or risk factors for tracheomalacia were prospectively studied. Volunteers were imaged with a 64-detector row scanner, with spirometric monitoring at total lung capacity and during forced exhalation, with 40 mAs, 120 kVp, and 0.625-mm detector collimation. Cross-sectional area and sagittal and coronal diameters of the trachea were measured 1 cm above the aortic arch and 1 cm above the carina. The percentage of expiratory collapse, the reduction in sagittal and coronal diameters, and the number of participants exceeding the current diagnostic criterion (> 50% expiratory reduction in cross-sectional area) for tracheomalacia were calculated.Results: The final study population included 25 men and 26 women (mean age, 50 years). The mean percentage of expiratory reduction in tracheal lumen cross-sectional area was 54.34% +/- 18.6 (standard deviation) in the upper trachea and 56.14% +/- 19.3 in the lower trachea. Forty (78%) participants exceeded the current diagnostic criterion for tracheomalacia in the upper and/or lower trachea. Decreases in cross-sectional area of the upper and lower trachea correlated well with decreases in sagittal (r = 0.807 and 0.688, respectively) and coronal (r = 0.779 and 0.751, respectively) diameters (P < .001 for each correlation).Conclusion: Healthy volunteers demonstrate a wide range of forced expiratory tracheal collapse, frequently exceeding the current diagnostic criterion for tracheomalacia. (C) RSNA, 2009