The Bone Microenvironment: a Fertile Soil for Tumor Growth.
The Bone Microenvironment: a Fertile Soil for Tumor Growth.
复制标题
骨微环境：肿瘤生长的肥沃土壤。
DOI：
10.1007/s11914-016-0315-2
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发表时间：
2016-08
影响因子：
4.3
通讯作者：
Sterling JA
中科院分区：
文献类型：
--
作者：
Buenrostro D;Mulcrone PL;Owens P;Sterling JA
骨转移疾病仍然是癌症患者的一个重要而频繁的问题，可能会导致发病率和死亡率的增加。不幸的是，尽管经过几十年的研究，骨转移仍然是无法治愈的。目前的研究表明，骨和骨髓微环境中的许多属性和细胞类型与肿瘤引起的骨病有关。此外，他们还指出了了解肿瘤细胞如何与其微环境相互作用的重要性，以帮助改进新疗法的开发和对治疗反应的预测。
Bone metastatic disease remains a significant and frequent problem for cancer patients that can lead to increased morbidity and mortality. Unfortunately, despite decades of research, bone metastases remain incurable. Current studies have demonstrated that many properties and cell types within the bone and bone marrow microenvironment contribute to tumor induced bone disease. Furthermore, they have pointed to the importance of understanding how tumor cells interact with their microenvironment in order to help improve both the development of new therapeutics and the prediction of response to therapy.