FACTORS ASSOCIATED WITH INTERSTITIAL PNEUMONITIS AFTER BONE-MARROW TRANSPLANTATION FOR ACUTE LEUKAEMIA
FACTORS ASSOCIATED WITH INTERSTITIAL PNEUMONITIS AFTER BONE-MARROW TRANSPLANTATION FOR ACUTE LEUKAEMIA
复制标题
急性白血病骨髓移植后与间质性肺炎相关的因素
DOI：
10.1016/s0140-6736(82)91633-6
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
A. Rimm
中科院分区：
文献类型：
--
作者：
M. Bortin;H. Kay;R. Gale;A. Rimm
对 1977 年 1 月 1 日至 1980 年 12 月 31 日期间接受同种异体骨髓移植并报告给国际骨髓移植登记处的 176 名急性白血病患者的数据进行回顾性分析，以了解与间质性肺炎 (IPn) 发展相关的预后因素。 IPn 的总体发病率为 20% (36/176)，36 例中有 21 例死亡 (58%)。研究的 30 多个预后因素中的 3 个似乎与 IPn 的低风险相关——与较高剂量率相比，剂量率 ≤5·7 cGy/min 的移植前全身照射 (p<0·001)；与甲氨蝶呤相比，使用环孢素 A 进行移植后免疫抑制 (p<0·0003)；与女性供体和男性受体相比，将女性供体的细胞移植到女性受体中（p<0·0005）。全身照射的低剂量率和环孢菌素 A 的使用被认为是自变量，但其混淆程度是无法确定一个或两个因素是否与 IPn 发生率降低相关。
Data from 176 patients with acute leukaemia given allogeneic marrow transplants between Jan. 1, 1977, and Dec. 31, 1980, and reported to the International Bone Marrow Transplant Registry were analysed retrospectively for prognostic factors associated with the development of interstitial pneumonitis (IPn). The overall incidence of IPn was 20% (36/176), and the disease was fatal in 21 of the 36 cases (58%). Three of more than thirty prognostic factors studied seemed to be associated with a low risk of IPn—pretransplant total body irradiation at a dose-rate ≤5·7 cGy/min, when compared with higher dose-rates (p<0·001); post-transplant immunosuppression with cyclosporin-A, when compared with methotrexate (p<0·0003); and transplantation of cells from female donors into female recipients, when compared with female donors and male recipients (p<0·0005). The low dose-rate of total body irradiation and the use of cyclosporin-A were considered as independent variables, but were confounded to the extent that it was not possible to determine if one or both factors were associated with a decreased incidence of IPn.
与白细胞输注相关的巨细胞病毒感染。
影响因子：
39.2
作者：
Winston,DJ;Ho,WG;Howell,CL;Miller,MJ;Mickey,R;Martin,WJ;Lin,CH;Gale,RP
通讯作者：
Gale,RP
人骨髓移植受者的肺泡巨噬细胞功能障碍。
DOI：
10.1016/0002-9343(82)90777-x
发表时间：
1982
期刊：
The American journal of medicine
影响因子：
--
作者：
Winston,DJ;Territo,MC;Ho,WG;Miller,MJ;Gale,RP;Golde,DW
通讯作者：
Golde,DW