Role of invariant natural killer T cells in lipopolysaccharide-induced pregnancy loss
Role of invariant natural killer T cells in lipopolysaccharide-induced pregnancy loss
复制标题
不变自然杀伤 T 细胞在脂多糖诱导的妊娠丢失中的作用。
DOI：
10.1016/j.cellimm.2013.10.007
复制
发表时间：
2013-11-01
影响因子：
4.3
通讯作者：
Lin, Yi
中科院分区：
文献类型：
--
作者：
Li, Liping;Shi, Lijuan;Lin, Yi
We aimed to investigate the role of invariant natural killer T (iNICI) cells in infection-associated pregnancy loss. Wild-type (WT) C57BL/6 mice and iNKT cell-deficient J alpha 18(-/-) mice were treated with lipopolysaccharide (LPS). Embryo resorption rates (ERRs), decidual costimulatory molecule and activation molecule expression, and cytokine production were determined. WT and J alpha 18(-/-) mice were adoptively transferred with purified iNKT cells. ERRs, decidual costimulatory molecule and activation molecule expression, and cytokine production were assessed. LPS-treated J alpha 18(-/-) mice showed markedly reduced ERRs, decreased CD40, CD80, CD86, and CD69 expression, and reduced Th1 cytokine production at the maternal-fetal interface compared with WT mice. ERRs, expression of CD40, CD80, CD86, and CD69, and Th1 cytokine production in LPS-injected J alpha 18(-/-) mice following iNKT cell adoptive transfer were remarkably upregulated compared with control mice that did not receive adoptively transferred iNKT cells. Our results suggest that iNKT cells play an important role in LPS-induced pregnancy loss. (C) 2013 Elsevier Inc. All rights reserved.
