Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy.
Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy.
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DOI：
10.1364/oe.18.008867
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发表时间：
2010-04-26
期刊：
影响因子：
3.8
通讯作者：
Emelianov S
中科院分区：
文献类型：
--
作者：
Chen YS;Frey W;Kim S;Homan K;Kruizinga P;Sokolov K;Emelianov S
光热稳定性以及因此等离子体纳米吸收体的光学吸收和光声响应的一致性对于成功的光声图像引导光热治疗是至关重要的。在这项研究中，二氧化硅包覆的金纳米棒被开发为一种多功能的分子成像和治疗剂，适用于图像引导的光热治疗。利用紫外-可见光谱和透射电子显微镜研究了二氧化硅包覆金纳米棒在纳秒激光脉冲强辐照下的光学性质和光热稳定性。二氧化硅包覆的金纳米棒表现出增加的光热稳定性，并在更高的能量密度下保持其上级光学性质。比较了聚乙二醇化纳米棒和二氧化硅包覆纳米棒在不同能量密度的激光脉冲下的光声响应变化。二氧化硅包覆的金纳米棒提供稳定的光声信号，这意味着更好的成像能力，并使二氧化硅包覆的金纳米棒成为光声成像和图像引导光热治疗的有前途的成像和治疗纳米剂。
Photothermal stability and, therefore, consistency of both optical absorption and photoacoustic response of the plasmonic nanoabsorbers is critical for successful photoacoustic image-guided photothermal therapy. In this study, silica-coated gold nanorods were developed as a multifunctional molecular imaging and therapeutic agent suitable for image-guided photothermal therapy. The optical properties and photothermal stability of silica-coated gold nanorods under intense irradiation with nanosecond laser pulses were investigated by UV-Vis spectroscopy and transmission electron microscopy. Silica-coated gold nanorods showed increased photothermal stability and retained their superior optical properties under much higher fluences. The changes in photoacoustic response of PEGylated and silica-coated nanorods under laser pulses of various fluences were compared. The silica-coated gold nanorods provide a stable photoacoustic signal, which implies better imaging capabilities and make silica-coated gold nanorods a promising imaging and therapeutic nano-agent for photoacoustic imaging and image-guided photothermal therapy.