Diagnostic efficacy of magnifying endoscopy with narrow-band imaging for gastric neoplasms: a meta-analysis.
Diagnostic efficacy of magnifying endoscopy with narrow-band imaging for gastric neoplasms: a meta-analysis.
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DOI：
10.1371/journal.pone.0123832
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Yan Z
中科院分区：
文献类型：
--
作者：
Lv X;Wang C;Xie Y;Yan Z
窄带成像放大内镜（ME-NBI）是一种新型的图像增强内镜技术，用于鉴别胃肠道肿瘤并可能实现病理诊断。本分析的目的是评估ME-NBI对胃肿瘤的诊断性能。我们对PubMed、EMbase、Web of Science和科克伦图书馆数据库进行了相关研究的系统检索。采用Meta-DiSc（1.4版）和STATA（11.0版）软件进行数据分析。随机效应模型用于评估诊断有效性。用Q统计量和I2统计量检验异质性。采用Meta回归分析异质性的来源。共纳入10项研究，2151处病变。这些研究的汇总特征如下：灵敏度0.85（95%置信区间[CI]：0.81-0.89），特异性0.96（95%置信区间[CI]：0.95-0.97），曲线下面积（AUC）0.9647。在比较ME-NBI和白色光成像（WLI）诊断功效的亚组分析中，ME-NBI的合并灵敏度和特异性分别为0.87（95%CI：0.80-0.92）和0.93（95%CI：0.90-0.95），曲线下面积（AUC）为0.9556。相比之下，WLI的合并灵敏度和特异性分别为0.61（95% CI：0.53-0.69）和0.65（95% CI：0.60-0.69），曲线下面积（AUC）为0.6772。ME-NBI对胃肿瘤有较高的诊断价值，特异性高。
Magnifying endoscopy with narrow-band imaging (ME-NBI) is a novel, image-enhanced endoscopic technique for differentiating gastrointestinal neoplasms and potentially enabling pathological diagnosis. The aim of this analysis was to assess the diagnostic performance of ME-NBI for gastric neoplasms. We performed a systematic search of the PubMed, EMbase, Web of Science, and Cochrane Library databases for relevant studies. Meta-DiSc (version 1.4) and STATA (version 11.0) software were used for the data analysis. Random effects models were used to assess diagnostic efficacy. Heterogeneity was tested by the Q statistic and I2 statistic. Meta-regression was used to analyze the sources of heterogeneity. A total of 10 studies, with 2151 lesions, were included. The pooled characteristics of these studies were as follows: sensitivity 0.85 (95% confidence interval [CI]: 0.81–0.89), specificity 0.96 (95% confidence interval [CI]: 0.95–0.97), and area under the curve (AUC) 0.9647. In the subgroup analysis, which compared the diagnostic efficacy of ME-NBI and white light imaging (WLI), the pooled sensitivity and specificity of ME-NBI were 0.87 (95% CI: 0.80–0.92) and 0.93 (95% CI: 0.90–0.95), respectively, and the area under the curve (AUC) was 0.9556. In contrast, the pooled sensitivity and specificity of WLI were 0.61 (95% CI: 0.53–0.69) and 0.65 (95% CI: 0.60–0.69), respectively, and the area under the curve (AUC) was 0.6772. ME-NBI presents a high diagnostic value for gastric neoplasms and has a high specificity.
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