EFFECT OF INTERNAL CAROTID ARTERY OCCLUSION ON MIDDLE CEREBRAL ARTERY BLOOD FLOW AT REST AND IN RESPONSE TO HYPERCAPNIA
EFFECT OF INTERNAL CAROTID ARTERY OCCLUSION ON MIDDLE CEREBRAL ARTERY BLOOD FLOW AT REST AND IN RESPONSE TO HYPERCAPNIA
复制标题
颈内动脉闭塞对静息状态下大脑中动脉血流的影响以及对高碳酸血症的反应
DOI：
10.1016/s0140-6736(86)91102-5
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
N. Browse
中科院分区：
文献类型：
--
作者：
C. Bishop;M. Insall;S. Powell;D. Rutt;N. Browse
在有症状的脑血管病患者中，用脉冲经颅多普勒血流速度计记录的高碳酸血症引起的大脑中动脉（MCA）血流速度的升高，在完全闭塞的颈动脉上方的MCA中显著低于在开放的颈动脉上方的MCA中。这些研究结果支持存在代偿性脑血管扩张以上的颈动脉闭塞，并表明短暂性脑缺血发作的患者颈动脉闭塞可能是流量相关的，而不是栓塞的现象。因此，这些患者可能受益于颅外-颅内手术血运重建。该方法是非侵入性的，因此非常适合用作筛查试验或随访研究。
In patients with symptomatic cerebrovascular disease the rise in middle cerebral artery (MCA) blood-flow velocity in response to hypercapnia, recorded with a pulsed transcranial doppler velocimeter, was significantly less in MCAs above a totally occluded carotid artery than in MCAs above a patent carotid. These findings support the existence of compensatory cerebral vasodilatation above a carotid occlusion and suggest that transient ischaemic attacks in patients with carotid occlusion may be flow-related rather than embolic phenomena. These patients may therefore benefit from extracranial-intracranial surgical revascularisation. The method presented is non-invasive and therefore ideally suited for use as a screening test or in follow-up studies.