Eukaryotic Translation Initiation Factors Shape RNA Viruses Resistance in Plants
Eukaryotic Translation Initiation Factors Shape RNA Viruses Resistance in Plants
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真核翻译起始因子影响植物对 RNA 病毒的抗性
DOI：
10.1016/j.hpj.2020.03.001
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发表时间：
2020-03-01
影响因子：
5.7
通讯作者：
Yang, Jinghua
中科院分区：
文献类型：
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作者：
Shopan, Jannat;Lv, Xiaolong;Yang, Jinghua
病毒是对农业生产的全球性威胁的代表。遗传抗性是控制病毒感染和防止作物产量损失的优选策略。病毒蛋白质合成需要宿主细胞因子来翻译它们的病毒RNA，并调节它们的复制和细胞到细胞的系统运动。因此，病毒依赖于细胞翻译因子。编码eIF4E和eIF4G或其异构体eIFiso4E、eIFiso4G和eIP2Bf3的基因中的突变已被定位为植物马铃薯Y病毒的来源，而许多物种中的其他植物病毒属的隐性抗性基因也起源于这些位点。一些其他的植物翻译因子，如eIF3、eIF4A样解旋酶、eEF1A和eEF1B，它们在与病毒RNA相互作用和调节感染周期的各个方面中是必需的，也已被鉴定。本文综述了真核植物RNA病毒的感染机制以及eIFs在病毒感染中的重要作用。此外，我们讨论了elFs作为靶基因在作物改良中对病毒的遗传抗性的发展中的潜力。这篇综述强调了新发现的异常翻译策略的例子，并提供了与3'帽非依赖性翻译增强子活性相关的天然宿主抗性机制的见解。
Viruses are representative of a global threat to agricultural production. Genetic resistance is the preferred strategy for the control of viral infection and against loss of crop yield. Viral protein synthesis requires host cellular factors for translating their viral RNAs, and for regulating their replication and cell to cell systemic movement. Therefore, the viruses are dependent on cellular translation factors. Mutations in the gene encoding eIF4E and eIF4G or their isoforms, eIFiso4E, eIFiso4G and elP2Bf3 have been mapped as a source of plant potyuirus while other genus of plant virus recessive resistance genes in many species are originated from these loci. Some of other plant translation factors, such as eIF3, eIF4A-like helicases, eEF1A and eEFIB, which are required in interacting with viral RNAs and regulating various aspects of the infection cycle, have also been identified. Here, we summarized the mechanisms utilized by RNA viruses of eukaryotic plants and the essential roles of elFs in virus infection. Moreover, we discussed the potential of elFs as a target gene in the development of genetic resistance to viruses for crop improvement. This review highlighted newly revealed examples of abnormal translational strategies and provided insights into natural host resistance mechanisms that have been linked to 3' cap-independent translational enhancer activity.