MYROIDES INFECTION IN A BABOON AFTER PROLONGED PIG KIDNEY GRAFT SURVIVAL.
MYROIDES INFECTION IN A BABOON AFTER PROLONGED PIG KIDNEY GRAFT SURVIVAL.
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DOI：
10.1097/txd.0000000000000523
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发表时间：
2015-05
影响因子：
2.3
通讯作者：
Cooper DK
中科院分区：
文献类型：
--
作者：
Liu H;Iwase H;Wijkstrom M;Singh J;Klein E;Wagner R;Humar A;Pasculle W;Cooper DK
免疫抑制患者和实验性非人灵长类动物有机会性感染的危险。我们报告了免疫抑制狒狒的Myroides spp感染，该狒狒接受了来自转基因猪的维持生命的肾脏。狒狒接受了基于共刺激阻断的免疫抑制方案以及两种抗炎药（托珠单抗和依那西普）。虽然猪肾功能良好，但移植后大约四个月，狒狒变得不那么活跃，饮食也不太好。第136天，尽管有肌力和液体支持，它还是崩溃死亡。据我们所知，在接受同种异体器官移植的患者或实验动物中，还没有关于Myroides spp作为机会性感染原因的报道。我们总结了关于这种罕见生物的已知情况，并建议在任何免疫功能低下的患者或动物中都应考虑这种情况。在目前的情况下，我们认为狒狒死于循环休克后感染通过留置静脉导管。
Immunosuppressed patients and experimental nonhuman primates are at risk of opportunistic infection. We report a Myroides spp infection in an immunosuppressed baboon that had received a life-supporting kidney from a genetically-engineered pig. The baboon received a costimulation blockade-based immunosuppressive regimen as well as two anti-inflammatory agents (tocilizumab and etanercept). Although the pig kidney functioned well, approximately four months after the transplant the baboon became less active and ate and drank poorly. On day 136, it collapsed and died despite inotropic and fluid support. A blood culture drawn before death grew Myroides spp. To our knowledge, Myroides spp has not been reported as a cause of opportunistic infection in either patients with organ allotransplants or experimental animals. We summarize what is known about this rare organism, and suggest it should be considered in any immunocompromised patient or animal. In the present case, we suggest the baboon died of circulatory shock following infection through an indwelling intravenous catheter.