25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease
25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease
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DOI：
10.1002/mds.24016
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发表时间：
2012-02-01
影响因子：
8.6
通讯作者：
Urashima, Mitsuyoshi
中科院分区：
文献类型：
--
作者：
Suzuki, Masahiko;Yoshioka, Masayuki;Urashima, Mitsuyoshi
我们旨在研究血清25-羟基维生素D水平、1，25-二氢维生素D水平、维生素D受体多态、维生素D结合蛋白基因多态和帕金森病严重程度之间的关系。在一项横断面研究中，对137例帕金森病患者进行了Hoehn&Yahr分级和统一帕金森病分级，并与25-羟基维生素D、1，25-羟基维生素D、维生素D受体多态，即FokI(Rs10735810)、BsmI(Rs1544410)、CDX2(Rs11568820)、Apai(Rs7976091)和Taqi(Rs731236)以及维生素D结合蛋白基因Gc1(Rs7041)/GC2(Rs4588)进行了比较。25-羟基维生素D的平均+/-标准偏差为21.1+/-9.0 ng/mL。水平是不足的(
We aimed to examine associations among serum 25-hydroxyvitamin D levels, 1,25-dihyroxyvitamin D levels, vitamin D receptor polymorphisms, vitamin D binding protein gene polymorphisms, and the severity of Parkinson's disease. In 137 patients, the severity of Parkinson's disease was evaluated using Hoehn & Yahr stage and Unified Parkinson's Disease Rating Stage by neurologists and compared with 25-hydroxyvitamin D, 1,25-hydroxyvitamin D, vitamin D receptor polymorphisms, ie, FokI (rs10735810), BsmI (rs1544410), Cdx2 (rs11568820), ApaI (rs7976091), and TaqI (rs731236), and vitamin D binding protein gene polymorphisms GC1 (rs7041)/GC2 (rs4588) in a cross-sectional study. Mean +/- standard deviation levels of 25-hydroxyvitamin D were 21.1 +/- 9.0 ng/mL. Levels were deficient (