The Nuclear Envelope and Cancer: A Diagnostic Perspective and Historical Overview
The Nuclear Envelope and Cancer: A Diagnostic Perspective and Historical Overview
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DOI：
10.1007/978-1-4899-8032-8_1
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Schirmer, Eric C.
中科院分区：
文献类型：
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作者：
de las Heras, Jose I.;Schirmer, Eric C.
癌症的诊断已经有几千年的历史了，但直到19世纪中叶显微镜的进步才开始了解它的细胞本质，当时显微镜的进步使人们能够对标本进行详细的观察。人们很快就注意到，癌细胞通常具有大小和/或形状发生变化的细胞核。这成为了癌症诊断的一个重要标准，至今仍在使用。直到20世纪下半叶，人们才开始了解核异常与癌症之间的联系，发现癌细胞与正常细胞的核膜成分不同。核膜不只是核内遗传物质和细胞质之间的物理屏障，而是许多细胞过程的非常重要的功能枢纽。在这篇综述中，我们概述了癌症生物学和核膜之间的联系，从显微镜的早期到今天对这些联系背后的一些分子机制的理解。
Cancer has been diagnosed for millennia, but its cellular nature only began to be understood in the mid-nineteenth century when advances in microscopy allowed detailed specimen observations. It was soon noted that cancer cells often possessed nuclei that were altered in size and/or shape. This became an important criterion for cancer diagnosis that continues to be used today. The mechanisms linking nuclear abnormalities and cancer only started to be understood in the second half of the twentieth century, with the discovery of nuclear lamina composition differences in cancer cells compared to normal cells. The nuclear envelope, rather than providing a mere physical barrier between the genetic material in the nucleus and the cytoplasm, is a very important functional hub for many cellular processes. In this review we give an overview of the links between cancer biology and nuclear envelope, from the early days of microscopy until the present day's understanding of some of the molecular mechanisms behind those links.