Enantioselective Total Synthesis of (-)-Euxanmodin B : An Axially Chiral Natural Product with an Anthraquinone-Xanthone Composite Structure
Enantioselective Total Synthesis of (-)-Euxanmodin B : An Axially Chiral Natural Product with an Anthraquinone-Xanthone Composite Structure
复制标题
(-)-Euxanmodin B 的对映选择性全合成：具有蒽醌-呫吨酮复合结构的轴向手性天然产物
DOI：
10.1002/asia.201100187
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Nobuyuki Takahashi
中科院分区：
文献类型：
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作者：
T. Miura;M. Ina;K. Imai;K. Nakashima;A. Masuda;N. Imai;N. Tada;A. Itoh;Nobuyuki Takahashi
密集功能化联芳基结构是嵌入在具有生物活性的天然产物[1]中的常见基序，如korupensamineA[1]和knipholone [3]它们通常具有围绕联芳基轴旋转受限的反旋异构性，这可能具有生物学意义，并为我们提供了合成挑战，包括以区域和对映体控制的方式构建立体拥挤的联芳基键。
Densely functionalized biaryl structures are common motifs embedded in biologically active natural products,[1] such as korupensamineA [2] and knipholone.[3] They often have atropisomerism with restricted rotation around the biaryl axis, which could have biological relevance and provide us with synthetic challenges, including construction of sterically congested biaryl linkages in a regio-and enantiocontrolled manner.