Muscle function in COPD: a complex interplay.
Muscle function in COPD: a complex interplay.
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DOI：
10.2147/copd.s28247
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发表时间：
2012
影响因子：
2.8
通讯作者：
Man WD
中科院分区：
文献类型：
--
作者：
Donaldson AV;Maddocks M;Martolini D;Polkey MI;Man WD
骨骼肌在生命中发挥着重要作用，为呼吸和运动提供机械基础。骨骼肌功能障碍普遍存在于慢性阻塞性肺病（COPD）的各个阶段，并显着影响症状、功能能力、健康相关生活质量、卫生资源使用甚至死亡率。此外，与肺相反，骨骼肌可以通过现有的治疗，即运动训练进行潜在的治疗。本文综述了呼吸和外周骨骼肌（特别是膈肌和四头肌）的临床和实验室观察，以及目前对潜在病因过程的理解。随着骨骼肌功能障碍的分子机制的阐明取得进一步进展，可能会出现新的药物疗法来治疗COPD的这种重要的肺外表现。
The skeletal muscles play an essential role in life, providing the mechanical basis for respiration and movement. Skeletal muscle dysfunction is prevalent in all stages of chronic obstructive pulmonary disease (COPD), and significantly influences symptoms, functional capacity, health related quality of life, health resource usage and even mortality. Furthermore, in contrast to the lungs, the skeletal muscles are potentially remedial with existing therapy, namely exercise-training. This review summarizes clinical and laboratory observations of the respiratory and peripheral skeletal muscles (in particular the diaphragm and quadriceps), and current understanding of the underlying etiological processes. As further progress is made in the elucidation of the molecular mechanisms of skeletal muscle dysfunction, new pharmacological therapies are likely to emerge to treat this important extra-pulmonary manifestation of COPD.