A meta-analysis of alcohol consumption in relation to risk of breast cancer.
A meta-analysis of alcohol consumption in relation to risk of breast cancer.
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饮酒与乳腺癌风险相关的荟萃分析。
DOI：
10.1001/jama.1988.03410050072032
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
T. Chalmers
中科院分区：
文献类型：
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作者：
M. Longnecker;J. Berlin;M. Orza;T. Chalmers
关于饮酒和乳腺癌风险之间关系的流行病学研究结果并不一致。我们对现有数据进行了荟萃分析(定量回顾)。为了评估饮酒和乳腺癌风险之间是否存在剂量-反应关系，我们对汇集的数据进行了数学模型拟合。在病例对照和随访流行病学数据中都有强有力的证据支持剂量-反应关系。使用我们计算的剂量-反应曲线，在病例对照数据中，每天摄入24克(1盎司)无水酒精(约每天两杯)相对于不饮酒者的乳腺癌风险为1.4(95%可信区间，1.0至1.8)，在随访数据中为1.7(95%可信区间，1.4至2.2)。我们认为这些发现并不是因果关系的证据，而是有力地支持了饮酒和乳腺癌风险之间的联系。
Epidemiologic findings regarding the relation between alcohol consumption and risk of breast cancer have been inconsistent. We performed a meta-analysis (a quantitative review) of the available data. To evaluate whether there was a dose-response relation between alcohol consumption and risk of breast cancer, we fitted mathematical models to the pooled data. There was strong evidence to support a dose-response relation in both the case-control and follow-up epidemiologic data. Using the dose-response curves that we calculated, the risk of breast cancer at an alcohol intake of 24 g (1 oz) of absolute alcohol daily (about two drinks daily) relative to nondrinkers was 1.4 (95% confidence interval, 1.0 to 1.8) in the case-control data and was 1.7 (95% confidence interval, 1.4 to 2.2) in the follow-up data. We interpret these findings not as proof of causality, but as strongly supportive of an association between alcohol consumption and risk of breast cancer.
Br.J.癌症。
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